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Case Reports
. 2022 Apr;28(4):903-905.
doi: 10.3201/eid2804.211433.

Legionella pneumophila Subspecies fraseri Infection after Allogeneic Hematopoietic Stem Cell Transplant, China

Xiaojuan Wang, Yifan Guo, Yawei Zhang, Qi Wang, Shuo Yang, Hua Yang, Tianyi Wang, Hui Wang
Case Reports

Legionella pneumophila Subspecies fraseri Infection after Allogeneic Hematopoietic Stem Cell Transplant, China

Xiaojuan Wang et al. Emerg Infect Dis. 2022 Apr.

Abstract

We describe an immunosuppressed patient with bacteremia and pneumonia caused by Legionella pneumophila subspecies fraseri in China. We confirmed this diagnosis by using nanopore sequencing of positive blood cultures and subsequent recovery from buffered-charcoal yeast extract culture. Nanopore sequencing is an effective tool for early diagnosis of atypical infections.

Keywords: China; Legionella pneumophila subsp. fraseri; Legionnaires’ disease; aHSCT; allogeneic hematopoietic stem cell transplant; bacteremia; bacteria; pneumonia; respiratory infections.

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Figures

Figure
Figure
Chest radiography and computed tomography images during acute infection with Legionella pneumophila subspecies fraseri after allogeneic hematopoietic stem cell transplant, China, 2021. A) May 13 (day 104), B) May 17 (day 108), C) May 24 (day 115), D) June 1 (day 123). Arrow in panel B indicates a large, solid, fuzzy shadow with unclear boundary, uneven internal density, and low-density plaques in the lower lobe of the right lung.
See this image and copyright information in PMC

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