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. 2022 Jan-Dec;14(1):2052698.
doi: 10.1080/19490976.2022.2052698.

The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota

Yongrong Zhang  1 , Ashley Saint Fleur  1 , Hanping Feng  1
Affiliations

The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota

Yongrong Zhang et al. Gut Microbes. 2022 Jan-Dec.

Abstract

Clostridioides difficile is the most prevalent pathogen of nosocomial diarrhea. In the United States, over 450,000 cases of C. difficile infection (CDI), responsible for more than 29,000 deaths, are reported annually in recent years. Because of the emergence of hypervirulent strains and strains less susceptible to vancomycin and fidaxomicin, new therapeutics other than antibiotics are urgently needed. The gut microbiome serves as one of the first-line defenses against C. difficile colonization. The use of antibiotics causes gut microbiota dysbiosis and shifts the status from colonization resistance to infection. Hence, novel CDI biotherapeutics capable of reconstituting normal gut microbiota have become a focus of drug development in this field.

Keywords: Clostridioides difficile; biotherapeutics; dysbiosis; microbiota; reconstitution.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
The role of gut microbiota in CDI development.
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