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Review
. 2022 Mar 25;8(12):eabp8322.
doi: 10.1126/sciadv.abp8322. Epub 2022 Mar 23.

Illuminating the lung regenerative potential of prostanoids

Sean M Fortier  1 , Loka R Penke  1 , Marc Peters-Golden  1
Affiliations
Review

Illuminating the lung regenerative potential of prostanoids

Sean M Fortier et al. Sci Adv. .

Abstract

PGE2 and PGI2 receptors are potential targets for the treatment of chronic lung disease.

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Figures

Fig. 1.
Fig. 1.. Potential actions of prostanoids in lung regeneration.
Prostanoids PGE2 and PGI2 are synthesized by and bind to G protein–coupled receptors in lung epithelial, mesenchymal, and immune cells. The resulting increase in intracellular levels of the second messenger cAMP reprograms gene expression in lung epithelial cells, including an up-regulation of circadian clock genes, promoting lung tissue repair and homeostasis. Administration of stable prostanoid agonists targeting the PGE2 receptors EP2 and EP4 and/or the PGI2 receptor IP may promote the regeneration of damaged lung in COPD and other chronic lung diseases. Credit: Kellie Holoski/Science Advances.
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