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. 2022 Mar 22;14(6):2513-2523.
doi: 10.18632/aging.203972. Epub 2022 Mar 22.

Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)

Yigit Cakiroglu  1   2 , Aysen Yuceturk  1 , Ozge Karaosmanoglu  1 , Sule Yildirim Kopuk  1 , Zeynep Ece Utkan Korun  1 , Nola Herlihy  3   4 , Richard T Scott  3   4 , Bulent Tiras  1   2 , Emre Seli  3   5
Affiliations

Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)

Yigit Cakiroglu et al. Aging (Albany NY). .

Abstract

The aim of the current study was to characterize ovarian reserve parameters and IVF outcomes in women with a history of poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Reproductive age women (N=510; age range 30-45yo) diagnosed with POR based on Poseidon criteria were included in the study. PRP treatment resulted in higher AFC, higher serum AMH, lower serum FSH, and a higher number of mature oocytes and cleavage and blastocyst stage embryos. After PRP injection, 22 women (4.3%) conceived spontaneously, 14 (2.7%) were lost to follow up, and 474 (92.9%) attempted IVF. Among women who attempted IVF, 312 (65.8%) generated embryos and underwent embryo transfer, 83 (17.5%) achieved a pregnancy, and 54 (11.4%) achieved sustained implantation/live birth (SI/LB). In total, of the 510 women with POR and mean age of 40.3, PRP resulted in improvement of ovarian reserve parameters, a pregnancy rate of 20.5% and SI/LB rate of 12.9%. Our findings suggest that PRP treatment may be considered in women with POR. For wider clinical application, its clinical efficacy will need to be demonstrated in prospective randomized clinical trials.

Keywords: in vitro fertilization; platelet rich plasma; poor ovarian response.

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Conflict of interest statement

CONFLICTS OF INTEREST: E.S. is a consultant for and receives research funding from the Foundation for Embryonic Competence.

Figures

Figure 1
Figure 1
Flowsheet of outcomes for all patients.
See this image and copyright information in PMC

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