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. 2022 May 5;386(18):1764-1766.
doi: 10.1056/NEJMc2201607. Epub 2022 Mar 23.

Neutralization Profile after Recovery from SARS-CoV-2 Omicron Infection

Annika Rössler  1 , Ludwig Knabl  2 , Dorothee von Laer  3 , Janine Kimpel  3
Affiliations

Neutralization Profile after Recovery from SARS-CoV-2 Omicron Infection

Annika Rössler et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Neutralization Capacity of Serum Samples Obtained from Patients Who Recovered from Infection with the Omicron BA.1 Variant.
Serum samples were obtained from 59 persons who had recovered from infection with the B.1.1.529 (omicron) BA.1 variant: 15 vaccinated persons without previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (Panel A); 18 unvaccinated persons without previous SARS-CoV-2 infection (Panel B); 11 vaccinated persons with previous infection with the D614G (wild-type), B.1.1.7 (alpha), or B.1.617.2 (delta) variant (Panel C); and 15 unvaccinated persons with previous infection with the wild-type, alpha, or delta variant (Panel D). Serum samples were obtained from each person 5 to 42 days after the first positive polymerase-chain-reaction assay during infection with the omicron BA.1 variant. Samples were analyzed for 50% neutralization titers (IC50) with the use of replication-competent wild-type, alpha, beta, P.1 (gamma), delta, or omicron BA.1 SARS-CoV-2 isolates. Individual values (circles) and mean titers (bars) are shown. Samples from the same person are connected by lines. Titers below 1:16 (dotted lines) are regarded as negative. In Panels B and D, the numbers above the bars indicate the proportions of samples that were positive for neutralizing antibodies against the respective variant. In Panels A and C, all the samples were positive for neutralizing antibodies against all the variants.
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References

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Supplementary concepts