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. 2022 Mar 16:15:1093-1101.
doi: 10.2147/IDR.S357193. eCollection 2022.

Clinical Study of Human Coronavirus NL63, OC43, 229E, HKU1 Infentions in Hospitalized Children from 2015 to 2020

Chan Wen #  1 , Ling Sun #  1 , Meng-Chuan Zhao  2 , Su-Xia Duan  2 , Le Wang  2 , Xiao-Wei Cui  3
Affiliations

Clinical Study of Human Coronavirus NL63, OC43, 229E, HKU1 Infentions in Hospitalized Children from 2015 to 2020

Chan Wen et al. Infect Drug Resist. .

Abstract

Objective: This study aims to analyze the clinical characteristics of hospitalized children infected with HCoV-NL63, OC43, 229E, HKU1 and provide the basis for disease diagnosis and treatment.

Methods: A retrospective analysis was conducted on clinical manifestations, imaging data, and treatment measures of hospitalized children with positive HCoV-NL63, OC43, 229E, HKU1 from 2015 to 2020.

Results: A total of 1062 children aged 33 days to 12 years were analyzed, including 879 (82.77%) between 33 days to three years. Lower respiratory tract infections were the most common in 698 children positive for HCoVs (65.72%). The incidences of runny nose, cough, pharyngeal hyperemia, and fine crackles in the mild case group (n = 894, 84.18%) were significantly higher than in the severe case group, and the differences were statistically significant (P < 0.01). The incidences of gasp, stridor, and convulsions, the proportion of underlying diseases, such as congenital heart disease, laryngomalacia, and general developmental disorders, anemia, and abnormal liver function, and mixed infections in the severe group (n = 168, 15.82%) were significantly higher than in the mild group, and the differences were statistically significant (P < 0.01 or P < 0.05). Imaging manifestations differed. Pleural effusion and atelectasis occurred in the severe cases. After treatment, patients fully recovered or improved and were discharged from the hospital. There were no deaths.

Conclusion: HCoV-NL63, OC43, 229E, HKU1 infection is most common in children under three years old, and the infection site is mainly the lower respiratory tract. The main clinical manifestations include fever, cough, and runny nose. Inspiratory three concave signs, respiratory failure, and heart failure occurred in the severe cases, with pleural effusion and atelectasis possibly occurring at the same time. Severe cases should be identified early so that they may be given comprehensive treatment in time to improve the prognosis.

Keywords: children; clinical characteristics; coronavirus; infection; respiratory tract.

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Conflict of interest statement

The authors declare that they have no competing interests in this work.

Figures

Figure 1
Figure 1
CT imaging findings of mild cases.
Figure 2
Figure 2
CT imaging findings of severe cases.
See this image and copyright information in PMC

References

    1. Zeng ZQ, Chen DH, Tan WP, et al. Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China. Eur J Clin Microbiol Infect Dis. 2018;37(2):363–369. doi: 10.1007/s10096-017-3144-z - DOI - PMC - PubMed
    1. Calvo C, Alcolea S, Casas I, et al. A 14-year prospective study of human coronavirus infections in hospitalized children: comparison with other respiratory viruses. Pediatr Infect Dis J. 2020;39(8):653–657. doi: 10.1097/INF.0000000000002760 - DOI - PubMed
    1. Li CC, Shang YX, Shen XZ, Chen ZM, Zhao SY. Guidelines for the management of community-acquired pneumonia in children (revised in 2013) (Part I). Chin J Pediatr. 2013;51(10):745–752. Chinese. - PubMed
    1. Jiang ZF, Shen KL. Pediatrics [M]. 8th ed. Beijing: People’s Medical Publishing House; 2015:1247. Chinese.
    1. Ottogalli ME, Rodríguez PE, Frutos MC, et al. Circulation of human coronaviruses OC43 and 229E in Córdoba, Argentina. Arch Virol. 2021;166(3):929–933. doi: 10.1007/s00705-020-04914-x - DOI - PMC - PubMed

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