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. 2020 Nov 23;2(1):zqaa032.
doi: 10.1093/function/zqaa032. eCollection 2021.

Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?

Javier Villadiego  1   2 , Reposo Ramírez-Lorca  1 , Fernando Cala  1 , José L Labandeira-García  2   3 , Mariano Esteban  4 , Juan J Toledo-Aral  1   2 , José López-Barneo  1   2
Affiliations

Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?

Javier Villadiego et al. Function (Oxf). .
No abstract available

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Figures

Figure 1.
Figure 1.
ACE2 Expression and Damage of CB O2-Sensing Cells by SARS-CoV-2 Infection. (A) Histological sections (thickness 10 µm) of human CB showing ACE2 and TH staining with selective antibodies. DAPI was used to stain cell nuclei. v, blood vessel. (B) Relative level of ACE2 mRNA expression in the CB tissue of the human subjects studied. RNA levels were calculated by qPCR with the 2−ΔΔCt method using the average ΔCt value as a reference. The dashed line indicates the value of ACE2 mRNA expression used for normalization. (C) Scheme illustrating the hypothetical consequences of infection of O2-sensing glomus cells by SARS-CoV-2.
See this image and copyright information in PMC

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