. 2022 Mar 7:9:790551.

doi: 10.3389/fcvm.2022.790551. eCollection 2022.

Kinetics of Cardiac Remodeling and Fibrosis Biomarkers During an Extreme Mountain Ultramarathon

Caroline Le Goff¹, Magalie Viallon^{2

3}, Jean-François Kaux⁴, Pierre Andonian⁵, Kevin Moulin^{2

3}, Laurence Seidel⁶, Guido Giardini⁷, Laurent Gergelé⁸, Pierre Croisille^{2

3}, Etienne Cavalier¹, Gregoire P Millet⁹

Affiliations

¹ Department of Clinical Chemistry, CHU de Liège, University of Liège, Liège, Belgium.
² Department of Radiology, University Hospital of Saint Etienne, Saint-Étienne, France.
³ CREATIS, CNRS (UMR 5220), INSERM (U1044), INSA Lyon, University of Lyon, Lyon, France.
⁴ Physical Medicine and Sport Traumatology Department, SportS2, IOC Research Centre for Prevention of Injury and Protection of Athlete Health, FIFA Medical Centre of Excellence, FIMS Collaborative Centre of Sports Medicine, University Hospital of Liège, University of Liège, Liège, Belgium.
⁵ Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
⁶ Biostatistics Department, University Hospital of Liège, Liège, Belgium.
⁷ Neurology Department, Valle d'Aosta Regional Hospital, Aosta, Italy.
⁸ Department of Anesthesiology, University Hospital of Saint Etienne, Saint-Étienne, France.
⁹ Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.

PMID: 35321109
PMCID: PMC8934929
DOI: 10.3389/fcvm.2022.790551

Kinetics of Cardiac Remodeling and Fibrosis Biomarkers During an Extreme Mountain Ultramarathon

Caroline Le Goff et al. Front Cardiovasc Med. 2022.

. 2022 Mar 7:9:790551.

doi: 10.3389/fcvm.2022.790551. eCollection 2022.

Authors

Affiliations

¹ Department of Clinical Chemistry, CHU de Liège, University of Liège, Liège, Belgium.
² Department of Radiology, University Hospital of Saint Etienne, Saint-Étienne, France.
³ CREATIS, CNRS (UMR 5220), INSERM (U1044), INSA Lyon, University of Lyon, Lyon, France.
⁴ Physical Medicine and Sport Traumatology Department, SportS2, IOC Research Centre for Prevention of Injury and Protection of Athlete Health, FIFA Medical Centre of Excellence, FIMS Collaborative Centre of Sports Medicine, University Hospital of Liège, University of Liège, Liège, Belgium.
⁵ Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
⁶ Biostatistics Department, University Hospital of Liège, Liège, Belgium.
⁷ Neurology Department, Valle d'Aosta Regional Hospital, Aosta, Italy.
⁸ Department of Anesthesiology, University Hospital of Saint Etienne, Saint-Étienne, France.
⁹ Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.

PMID: 35321109
PMCID: PMC8934929
DOI: 10.3389/fcvm.2022.790551

Abstract

Objectives: The effects of ultra-distance on cardiac remodeling and fibrosis are unclear. Moreover, there are no data reporting the kinetics of cardiac alterations throughout the event and during recovery. Our aim was to investigate the kinetics of biological markers including new cardiac fibrosis biomarkers suppression of tumorigenicity 2 (ST2) and galectin-3 (Gal-3) during and after an extreme mountain ultramarathon.

Methods: Fifty experienced runners participating in one of the most challenging mountain ultramarathons (330 km, D+ 25,000 m) were enrolled in our study. Blood samples were collected at four time points: before (Pre-), at 148 km (Mid-), at the finish line (Post-), and 3 days after the recovery period (Recov-).

Results: The cardiac fibrosis biomarkers (ST2 and Gal-3) increased from Pre- to Mid-. During the second half, ST2 remained higher than pre-values as opposed to Gal-3. Necrosis, ischemia, and myocyte injury biomarkers increased until Mid- then decreased but remained higher at Recov- than Pre-values. Oxidative stress appeared at Mid-. Lipid peroxides remained higher at Recov- compared to Pre-. The maximal value in most of these biomarkers was observed at Mid- and not at Post-.

Conclusions: The present study supports biphasic kinetics of cardiac fibrosis biomarkers, with a relative recovery during the second half of the event that seems specific to this extreme event. Overall, performing at such an extreme ultramarathon seems less deleterious for the heart than shorter events.

Keywords: ST2; cardiac biomarker; cardiac fibrosis markers; galectin-3; ultramarathon running.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Kinetics of Cardiac Remodeling and Fibrosis Biomarkers During an Extreme Mountain Ultramarathon

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Kinetics of Cardiac Remodeling and Fibrosis Biomarkers During an Extreme Mountain Ultramarathon

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Abstract

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