Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar-Apr;26(2):137-142.
doi: 10.4103/jisp.jisp_74_21. Epub 2022 Mar 1.

Comparative evaluation of implant stability with and without autologous platelet-rich fibrin prior to prosthetic loading - A split-mouth randomized clinical trial

Anjali Kapoor  1 , A Rizwan Ali  1 , Neha Saini  1 , Kompal Gautam  2 , Akansha Goyal  1 , Vasundhara Prakash  1
Affiliations

Comparative evaluation of implant stability with and without autologous platelet-rich fibrin prior to prosthetic loading - A split-mouth randomized clinical trial

Anjali Kapoor et al. J Indian Soc Periodontol. 2022 Mar-Apr.

Abstract

Context: Status of bone-implant interface or osseointegration can be assessed by using resonance frequency analysis (RFA), which measures implant stability. A modified implant surface can significantly enhance osseointegration and reduce healing period. Platelet-rich fibrin (PRF) consists of fibrin mesh with entrapped platelets and leukocytes that release a huge number of growth factors which contribute to wound healing and tissue regeneration.

Aims: The present study aims to evaluate the effect of PRF on osseointegration in terms of implant stability.

Settings and design: This was a split-mouth randomized clinical trial.

Materials and methods: Sixty surgical sites were divided randomly into two groups. In Group 1 (thirty sites), PRF was placed in osteotomy sites before implant placement whereas no PRF was placed in Group 2 (thirty sites). Stability was measured using RFA in terms of implant stability quotient (ISQ) at baseline, 1 week, 1 month, and 3 months.

Statistical analysis: Intergroup comparison was done using Mann-Whitney U-test. Intragroup comparison was done using Friedman's test followed by pairwise comparison using Wilcoxon signed-rank test.

Results: On intergroup comparison, Group 1 showed higher values for ISQ which were statistically significant (P < 0.05) at 1 week and 1 month. No significant difference (P > 0.05) was found at baseline and 3 months. Intragroup comparison and further pairwise comparison revealed a highly significant difference for values between all pairs of time intervals (P < 0.01) with higher values at 3 months.

Conclusions: PRF has a significant effect on osseointegration of dental implants during the early healing period prior to loading.

Keywords: Dental implants; implant stability; osseointegration; platelet-rich fibrin; resonance frequency analysis.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Zohrabian VM, Sonick M, Hwang D, Abrahams JJ. Dental implants. Semin Ultrasound CT MR. 2015;36:415–26. - PubMed
    1. Buser D, Chen ST, Weber HP, Belser UC. Early implant placement following single-tooth extraction in the esthetic zone: Biologic rationale and surgical procedures. Int J Periodontics Restorative Dent. 2008;28:441–51. - PubMed
    1. Jayesh RS, Dhinakarsamy V. Osseointegration. J Pharm Bioallied Sci. 2015;7:S226–9. - PMC - PubMed
    1. Weigl P. Implant prosthodontics: What next? Quintessence Int. 2003;34:653–69. - PubMed
    1. Brånemark R, Ohrnell LO, Nilsson P, Thomsen P. Biomechanical characterization of osseointegration during healing: An experimental in vivo study in the rat. Biomaterials. 1997;18:969–78. - PubMed