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. 2022 Apr;53(3):252-262.
doi: 10.1016/j.arcmed.2022.03.001. Epub 2022 Mar 14.

COVID-19 in Neonates with Positive RT-PCR Test. Systematic Review

Heladia García  1 , Aldo Allende-López  2 , Paulina Morales-Ruíz  2 , Guadalupe Miranda-Novales  3 , Miguel Ángel Villasis-Keever  4
Affiliations

COVID-19 in Neonates with Positive RT-PCR Test. Systematic Review

Heladia García et al. Arch Med Res. 2022 Apr.

Abstract

Background: COVID-19 is an infectious disease of variable severity caused by a new coronavirus. Clinical presentation ranges from asymptomatic cases to severe illness. Most cases in newborns appear to be asymptomatic or mild.

Objective: To conduct a systematic review of the literature on published studies of COVID-19 in newborns with a positive RT-PCR test.

Methods: The PubMed and EMBASE databases were searched for infection data in newborns from 1 December 2019-21 May 2021. The mesh terms included "SARS-CoV-2", "COVID-19", "novel coronavirus", "newborns" and "neonates". The selection criteria were as follows: original studies reporting clinical, radiological, laboratory, and outcome data in newborns with a positive RT-PCR test for SARS-CoV-2. Two independent investigators reviewed the studies.

Results: Seventy-two studies that involved 236 newborns were included. The main clinical manifestations were fever (43.2%), respiratory (46.6%), and gastrointestinal (35.2%) symptoms; 60.1% had mild/moderate disease. A total of 52.5% had a chest X-ray; 43.5% were normal, and 24.1% reported consolidation/infiltration images. The most frequent laboratory abnormalities were elevated C reactive protein and elevated procalcitonin and lymphopenia. Mortality was 1.7%.

Conclusion: Symptoms of SARS-CoV-2 infection were mild to moderate in most of the newborns. The prognosis was good, and mortality was mainly associated with other comorbidities.

Keywords: COVID-19; Neonate; Newborn; Novel coronavirus; SARS-CoV-2; Systematic review.

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Figures

Figure 1
Figure 1
Flow diagram (PRISMA) of the study selection process.
Figure 2
Figure 2
Clinical characteristics in 236 neonates with SARS-CoV-2 infection.
See this image and copyright information in PMC

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