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Case Reports
. 2022 Mar 23;15(3):e247281.
doi: 10.1136/bcr-2021-247281.

Primary mucoepidermoid carcinoma of the breast arising in adenomyoepithelioma

Chau M Bui  1 , Shikha Bose  2
Affiliations
Case Reports

Primary mucoepidermoid carcinoma of the breast arising in adenomyoepithelioma

Chau M Bui et al. BMJ Case Rep. .

Abstract

Mucoepidermoid carcinoma (MEC) and adenomyoepithelioma (AME) are uncommon neoplasms of the breast that are more commonly noted in the salivary glands. AMEs are benign tumours that are known to undergo malignant transformation. This report describes the first case of a MEC arising in AME in a woman in her 50s.

Keywords: Breast cancer; Pathology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
(A) Ultrasound, (B) MRI and (C) mammogram of the breast lesion (arrows).
Figure 2
Figure 2
(A) Tumour at 20× magnification, (B) adenomyoepithelioma (AME) at 100× magnification, (C) AME at 200× magnification, (D) dual stain of Oscar (pink) highlights epithelial cells and p63 (brown) highlights myoepithelial cells, (E) smooth muscle myosin stain (SMMS) highlights myoepithelial cells, (F) calponin stain highlights myoepithelial cells, (G) mucoepidermoid carcinoma (MEC) at 40× magnification, (H) AME with MEC differentiation, (I) SMMS is positive in myoepithelial cells in AME and negative in MEC differentiation, (J) epidermoid and intermediate cells, (K) dual stain of Oscar (pink) and p63 (brown) highlight epidermoid and intermediate cells, (L) p40 stain highlights epidermoid and intermediate cells, (M) mucocytes, (N) mucicarmine highlights mucocytes and extracellular mucin, (O) invasive MEC and (P) SMMS is negative in invasive MEC.
See this image and copyright information in PMC

References

    1. Fisher ER, Palekar AS, Gregorio RM, et al. . Mucoepidermoid and squamous cell carcinomas of breast with reference to squamous metaplasia and giant cell tumors. Am J Surg Pathol 1983;7:15–28. 10.1097/00000478-198301000-00002 - DOI - PubMed
    1. Hayes MM, Lesack D, Girardet C, et al. . Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type. Virchows Arch 2005;446:142–9. 10.1007/s00428-004-1137-7 - DOI - PubMed
    1. Ye R-P, Liao Y-H, Xia T, et al. . Breast mucoepidermoid carcinoma: a case report and review of literature. Int J Clin Exp Pathol 2020;13:3192–9. - PMC - PubMed
    1. Basbug M, Akbulut S, Arikanoglu Z, et al. . Mucoepidermoid carcinoma in a breast affected by burn scars: comprehensive literature review and case report. Breast Care 2011;6:293–7. 10.1159/000331316 - DOI - PMC - PubMed
    1. Jones C, Ford E, Gillett C, et al. . Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes. Clin Cancer Res 2004;10:5988–97. 10.1158/1078-0432.CCR-03-0731 - DOI - PubMed

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