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Review
. 2022 May;47(5):96.
doi: 10.3892/or.2022.8307. Epub 2022 Mar 24.

Regulatory functions of miR‑200b‑3p in tumor development (Review)

Sheng Chen #  1 , Yifeng Tu #  2 , Hang Yuan #  1 , Zhan Shi  2 , Yang Guo  1 , Wenjing Gong  1 , Shiliang Tu  1
Affiliations
Review

Regulatory functions of miR‑200b‑3p in tumor development (Review)

Sheng Chen et al. Oncol Rep. 2022 May.

Abstract

MicroRNAs (miRNAs/miRs), non‑coding single‑stranded RNAs of length 18‑24 nucleotides, can modulate gene expression through post‑transcriptional control. As such, they can influence tumor proliferation, apoptosis, invasion, metastasis as well as chemotherapy resistance by regulating certain downstream genes. In this context, miR‑200b‑3p, one particular member of the miR‑200 family, possesses the ability to suppress tumor progression. However, many studies have suggested that, in certain cases, this miRNA may also promote the development of some tumors due to differences in the microenvironments and molecular backgrounds of different cancers. This review summarizes previous studies on the involvement of miR‑200b‑3p in tumors, including the underlying mechanism.

Keywords: ZEB1/2; cancer; miRNA; miR‑200b‑3p.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Functions and mechanism of miR-200b-3p in various types of cancers. EMT, epithelial-mesenchymal transition. Note: all expanded full names for the gene symbols can be found in Table I legend.
Figure 2.
Figure 2.
Regulation of miR-200b-3p expression. ncRNAs, non-coding RNAs; ceRNA, competing endogenous RNA; TFs, transcription factors; EMT, epithelial-mesenchymal transition.
See this image and copyright information in PMC

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