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Review
. 2022 Mar 4;9(3):22.
doi: 10.3390/medicines9030022.

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

Saroj K Pradhan  1   2   3 , Yiming Li  1   2   3 , Andreas R Gantenbein  4 , Felix Angst  5 , Susanne Lehmann  5 , Hamdy Shaban  6
Affiliations
Review

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

Saroj K Pradhan et al. Medicines (Basel). .

Abstract

Background: Chinese herbal medicine is considered relatively safe, inexpensive, and easily accessible. Wen Dan Tang (WDT), a Jing Fang ancient classical Chinese herbal formula with a broad indication profile has been used for several centuries in China to treat various illnesses.

Question: Are there evidence-based clinical trials that show that WDT has a significant impact on the treatment of various diseases, especially in patients with migraine and tension-type headaches (TTH)?

Methods: This study is based on an online database search using PubMed, Medline, Cochrane Library, AcuTrials, Embase, Semantic Scholar, Jstor, internet research, and review of ancient and modern Chinese medical textbooks regarding WDT and its compounds.

Results: There were no studies on WDT in migraine and TTH; therefore, this work gathers and describes data for every single compound in the formula.

Conclusion: This study suggests that the bioactive compounds found in WDT composition show potential in treating patients with neurological, psychiatric disorders, cardiovascular diseases, metabolic syndrome, and digestive disorders. Some coherence between WDT in headache reduction and improvements in the quality of life in patients with migraines and TTH could be evaluated, showing positive results of WDT in these patients.

Keywords: Chinese herbal medicine; Wen Dan Tang; headache disorders; migraine; tension-type headache; traditional Chinese medicine.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. NATCM. [(accessed on 14 September 2020)];2018 Available online: http://kjs.satcm.gov.cn/zhengcewenjian/2018-04-16/7107.html.
    1. Zhang B., Qi D., Deng X., Ma Z., Wu Y., Xue Z., Kebebe D., Lu P., Pi J., Guo P. Quantification of nineteen bioactive components in the ancient classical Chinese medicine formula of Wen-Dan decoction and its commercial preparations by UHPLC-QQQ-MS/MS. Molecules. 2019;24:2031. doi: 10.3390/molecules24112031. - DOI - PMC - PubMed
    1. Su T., Tan Y., Tsui M.-S., Yi H., Fu X.-Q., Li T., Chan C.L., Guo H., Li Y.-X., Zhu P.-L., et al. Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing. Sci. Rep. 2016;6:34692. doi: 10.1038/srep34692. - DOI - PMC - PubMed
    1. Seok J.K., Kwak J.Y., Seo H.H., Suh H.J., Boo Y.C. Effects of Bambusae caulis in Taeniam extract on the UVB-induced cell death, oxidative stress and matrix metalloproteinase 1 expression in keratinocytes. J. Soc. Cosmet. Sci. Korea. 2015;41:9–20.
    1. Kim A., Im M., Yim N.-H., Jung Y.P., Ma J.Y. Aqueous extract of Bambusae Caulis in Taeniam inhibits PMA-induced tumor cell invasion and pulmonary metastasis: Suppression of NF-κB activation through ROS signaling. PLoS ONE. 2013;8:e78061. doi: 10.1371/journal.pone.0078061. - DOI - PMC - PubMed

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