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Multicenter Study
. 2022 Nov;159(2):550-556.
doi: 10.1002/ijgo.14190. Epub 2022 Apr 14.

OPEC study: An international multicenter study of ovarian preservation in endometrial cancers

Utku Akgor  1 , Ali Ayhan  2 , Alexander Shushkevich  3 , Bulent Ozdal  4 , Kyveli Angelou  5 , Ozgur Akbayır  6 , Dilyara Kaidarova  7 , Elena Ulrikh  8 , Artem Stepanyan  9 , Fırat Ortac  10 , Shamistan Aliyev  11 , Nejat Ozgul  1 , Siarhei Taranenka  3 , Ali Haberal  2 , Coskun Salman  1 , Alper Seyhan  6 , Ilker Selcuk  4 , Dimitrios Haidopoulos  5 , Huseyin Akıllı  2 , Raikhan Bolatbekova  7 , Areg Alaverdyan  9 , Salih Taskin  10 , Sabina Murshudova  11 , Meltem Batur  1 , Igor Berlev  8 , Murat Gultekin  1
Affiliations
Multicenter Study

OPEC study: An international multicenter study of ovarian preservation in endometrial cancers

Utku Akgor et al. Int J Gynaecol Obstet. 2022 Nov.

Abstract

Objective: To evaluate the feasibility and oncological safety of ovarian preservation in early stage endometrial adenocarcinoma (EC) patients aged 40 and below.

Methods: A total of 11 institutions from eight countries participated in the study. 169 of 5898 patients aged ≤40 years were eligible for the study. Patients with EC treated between March 2007 and January 2019 were retrospectively assessed.

Results: The median duration of follow-up after EC diagnosis was 59 months (4-187). Among 169 participants, ovarian preservation surgery (OPS) was performed in 54 (31.9%), and BSO was performed in 115 (68.1%) patients. Although patients younger than 30 years of age were more likely to have OPS than patients aged 30 to 40 years (20.4% vs. 9.6%, P = 0.021), there was no significant difference by the mean age. There were no other relevant baseline differences between OPS and BSO groups. The Kaplan-Meier analysis revealed no difference in either the overall survival (P = 0.955) or recurrence-free survival (P = 0.068) among patients who underwent OPS, and BSO.

Conclusion: OPS appears to be safe without having any adverse impact on survival in women aged ≤40 years with FIGO Stage I EC.

Keywords: early-stage; endometrial cancer; ovarian preservation; young women.

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References

REFERENCES

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