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Comment
. 2022 Apr 5;119(14):e2203036119.
doi: 10.1073/pnas.2203036119. Epub 2022 Mar 24.

Spring-like behavior of cytoplasm holds the mitotic spindle in place

Luolan Bai  1   2 , Timothy J Mitchison  1
Affiliations
Comment

Spring-like behavior of cytoplasm holds the mitotic spindle in place

Luolan Bai et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Viscoelastic forces from bulk cytoplasm maintain the spindle position. (A) The experimental procedure for displacing mitotic spindles with magnetic tweezers. (B) Viscoelasticity modeled by spring–dashpot models. In small cells where microtubules touch the cortex, microtubules constitute the main elastic component. In large cells, in contrast, bulk cytoplasm generates viscoelastic restoring forces. (C) Cytoplasmic components implicated in force generation. Passive components resist perturbations, while active components generate force using chemical energy.
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References

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