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. 2022 Sep 8;16(9):1475-1492.
doi: 10.1093/ecco-jcc/jjac041.

Systematic Review: The Impact and Importance of Body Composition in Inflammatory Bowel Disease

Nik Sheng Ding  1   2 , Daniel Tassone  2 , Ibrahim Al Bakir  1 , Kyle Wu  2 , Alexander J Thompson  2 , William R Connell  2 , George Malietzis  3 , Phillip Lung  1 , Siddharth Singh  4 , Chang-Ho Ryan Choi  1 , Simon Gabe  1 , John T Jenkins  3 , Ailsa Hart  1
Affiliations

Systematic Review: The Impact and Importance of Body Composition in Inflammatory Bowel Disease

Nik Sheng Ding et al. J Crohns Colitis. .

Abstract

Background and aims: Alterations in body composition are common in inflammatory bowel disease [IBD] and have been associated with differences in patient outcomes. We sought to consolidate knowledge on the impact and importance of body composition in IBD.

Methods: We performed a systematic search of MEDLINE, EMBASE and conference proceedings by combining two key research themes: inflammatory bowel disease and body composition.

Results: Fifty-five studies were included in this review. Thirty-one focused on the impact of IBD on body composition with a total of 2279 patients with a mean age 38.4 years. Of these, 1071 [47%] were male. In total, 1470 [64.5%] patients had Crohn's disease and 809 [35.5%] had ulcerative colitis. Notably, fat mass and fat-free mass were reduced, and higher rates of sarcopaenia were observed in those with active IBD compared with those in clinical remission and healthy controls. Twenty-four additional studies focused on the impact of derangements in body composition on IBD outcomes. Alterations in body composition in IBD are associated with poorer prognoses including higher rates of surgical intervention, post-operative complications and reduced muscle strength. In addition, higher rates of early treatment failure and primary non-response are seen in patients with myopaenia.

Conclusions: Patients with IBD have alterations in body composition parameters in active disease and clinical remission. The impacts of body composition on disease outcome and therapy are broad and require further investigation. The augmentation of body composition parameters in the clinical setting has the potential to improve IBD outcomes in the future.

Keywords: Body composition; fat mass; inflammatory bowel disease; muscle mass.

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Figures

Figure 1.
Figure 1.
PRISMA flow diagram.
Figure 2.
Figure 2.
Diagram representing the attenuated muscle hypertrophy pathway as reflected by signalling factor levels in CD.
See this image and copyright information in PMC

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