Concordance of Blood-Based and Normal Tissue-Based Dihydropyrimidine Dehydrogenase (DPYD) Genotyping
- PMID: 35325223
- PMCID: PMC9075005
- DOI: 10.1093/oncolo/oyac057
Concordance of Blood-Based and Normal Tissue-Based Dihydropyrimidine Dehydrogenase (DPYD) Genotyping
Abstract
In response to the recently published article by Sharma et al, this letter to the editor presents data about the concordance of blood and normal tissue-based evaluation of DPYD genotyping that suggests that pharmacogenetic screening could be contextual to tumor molecular profiling.
Comment in
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In Reply.Oncologist. 2022 May 6;27(5):e422. doi: 10.1093/oncolo/oyac058. Oncologist. 2022. PMID: 35325206 Free PMC article.
Comment on
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Pathogenic DPYD Variants and Treatment-Related Mortality in Patients Receiving Fluoropyrimidine Chemotherapy: A Systematic Review and Meta-Analysis.Oncologist. 2021 Dec;26(12):1008-1016. doi: 10.1002/onco.13967. Epub 2021 Sep 29. Oncologist. 2021. PMID: 34506675 Free PMC article.
References
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- Henricks LM, Lunenburg CATC, de Man FM, et al. . DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis. Lancet Oncol. 2018;19(11):1459-1467. - PubMed
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- European Medicines Agency. 5-Fluorouracil (i.v.), capecitabine and tegafur containing products: pre-treatment testing to identify DPD deficient patients at increased risk of severe toxicity. Available at https://www.ema.europa.eu/en/medicines/dhpc/5-fluorouracil-iv-capecitabi.... Accessed September 28, 2021
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- USFDA. Table of Pharmacogenetic Associations. FDA. 2020. Available at: https://www.fda.gov/medical-devices/precision-medicine/tablepharmacogene.... Accessed October 18, 2021
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