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. 2022 Aug;122(4):871-880.
doi: 10.1007/s13760-022-01920-5. Epub 2022 Mar 24.

The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review

Wefa Boughrara  1   2   3 , Amina Chentouf  4   5
Affiliations

The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review

Wefa Boughrara et al. Acta Neurol Belg. 2022 Aug.

Abstract

Despite a dramatic increase in treatment options over the past 30 years, Carbamazepine (CBZ) is still considered the standard of care and the most prescribed initial treatment for focal epilepsy. Hence, the identification of genetic biomarkers that influence the response, resistance and toxicity to CBZ remains a challenge. Several research studies have looked into this to highlight the polymorphisms responsible for the variability in the response to CBZ in patients with epilepsy. The aim of this review is to compare the different results published in the literature The systematic review included thirty-nine studies (2005-2021), Meta-analyses were performed on more than twelve polymorphisms in three genes (ABCB1, ABCC2, RALBP1) involved in CBZ cell transport. The current challenges are to identify other new biomarkers of antiepileptic drugs that can only materialize with large-scale collaborative research efforts.

Keywords: Carbamazepine; Epilepsy; Pharmacogenetic; Polymorphism.

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References

    1. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE et al (2014) ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55(4):475–482 - DOI - PubMed
    1. Singh A, Trevick S (2016) The epidemiology of global epilepsy. Neurol Clin 34:837–847. https://doi.org/10.1016/j.ncl.2016.06.015 - DOI - PubMed
    1. Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon C-S, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N (2017) Prevalence and incidence of epilepsy A systematic review and meta-analysis of international studies. Neurology 88(3):296–303 - PubMed - PMC - DOI
    1. Beghi E (2020) The epidemiology of epilepsy. Neuroepidemiology 54:185–191 - PubMed - DOI
    1. Loscher W, Klitgaard H, Twyman RE, Schmidt D (2013) New avenues for anti-epileptic drug discovery and development. Nat Rev Drug Discov 12:757–776. https://doi.org/10.1038/nrd4126 - DOI - PubMed

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