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. 2022 Mar 12;11(6):983.
doi: 10.3390/cells11060983.

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Urna Kansakar  1 , Fahimeh Varzideh  1 , Pasquale Mone  1 , Stanislovas S Jankauskas  1   2 , Gaetano Santulli  1   2
Affiliations

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Urna Kansakar et al. Cells. .

Abstract

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

Keywords: apoptosis; autophagy; cardiomyocytes; cell death; heart failure; ischemia/reperfusion; myocardial infarction; necrosis; non-coding RNA.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram depicting miRNAs orchestrating myocardial cell apoptosis, necrosis, and autophagy in myocardial infarction.
See this image and copyright information in PMC

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