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. 2022 Mar 21;11(6):1054.
doi: 10.3390/cells11061054.

NAADP Signaling: New Kids on the Block

Andreas H Guse  1
Affiliations

NAADP Signaling: New Kids on the Block

Andreas H Guse. Cells. .

Abstract

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a universal Ca2+ mobilizing second messenger essential for initiation of Ca2+ signaling. Recently, novel molecular mechanisms of both its rapid formation upon receptor stimulation and its mode of action were discovered. Dual NADPH oxidase 2 (DUOX2) and hematological and neurological expressed 1-like protein (HN1L)/Jupiter microtubule-associated homolog 2 (JPT2) were discovered as NAADP-forming enzyme and NAADP receptor/binding protein-the new kids on the block. These novel aspects are reviewed and integrated into the previous view of NAADP signaling.

Keywords: Ca2+ microdomains; Ca2+ signaling; NAADP; dual NADPH oxidase (DUOX); hematological and neurological expressed 1-like protein (HN1L)/Jupiter microtubule-associated homolog 2 (JPT2); ryanodine receptor (RYR); two-pore channel (TPC).

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
NAADPH/NAADP redox cycle and fill-up and degradation reactions.
Figure 2
Figure 2
Ca2+ mobilization by NAADP mediated by NAADP receptors/binding proteins linking to different organelles and ion channels.
See this image and copyright information in PMC

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References

    1. Lee H.C., Aarhus R. A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. J. Biol. Chem. 1995;270:2152–2157. doi: 10.1074/jbc.270.5.2152. - DOI - PubMed
    1. Berg I., Potter B.V., Mayr G.W., Guse A.H. Nicotinic acid adenine dinucleotide phosphate (NAADP+) is an essential regulator of T-lymphocyte Ca2+-signaling. J. Cell Biol. 2000;150:581–588. doi: 10.1083/jcb.150.3.581. - DOI - PMC - PubMed
    1. Burdakov D., Galione A. Two neuropeptides recruit different messenger pathways to evoke Ca2+ signals in the same cell. Curr. Biol. 2000;10:993–996. doi: 10.1016/S0960-9822(00)00649-7. - DOI - PubMed
    1. Cancela J.M., Churchill G.C., Galione A. Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells. Nature. 1999;398:74–76. doi: 10.1038/18032. - DOI - PubMed
    1. Clapper D.L., Walseth T.F., Dargie P.J., Lee H.C. Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate. J. Biol. Chem. 1987;262:9561–9568. doi: 10.1016/S0021-9258(18)47970-7. - DOI - PubMed

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