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. 2022 Mar 21;11(6):1054.
doi: 10.3390/cells11061054.

NAADP Signaling: New Kids on the Block

Andreas H Guse  1
Affiliations

NAADP Signaling: New Kids on the Block

Andreas H Guse. Cells. .

Abstract

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a universal Ca2+ mobilizing second messenger essential for initiation of Ca2+ signaling. Recently, novel molecular mechanisms of both its rapid formation upon receptor stimulation and its mode of action were discovered. Dual NADPH oxidase 2 (DUOX2) and hematological and neurological expressed 1-like protein (HN1L)/Jupiter microtubule-associated homolog 2 (JPT2) were discovered as NAADP-forming enzyme and NAADP receptor/binding protein-the new kids on the block. These novel aspects are reviewed and integrated into the previous view of NAADP signaling.

Keywords: Ca2+ microdomains; Ca2+ signaling; NAADP; dual NADPH oxidase (DUOX); hematological and neurological expressed 1-like protein (HN1L)/Jupiter microtubule-associated homolog 2 (JPT2); ryanodine receptor (RYR); two-pore channel (TPC).

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
NAADPH/NAADP redox cycle and fill-up and degradation reactions.
Figure 2
Figure 2
Ca2+ mobilization by NAADP mediated by NAADP receptors/binding proteins linking to different organelles and ion channels.
See this image and copyright information in PMC

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