Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 19;12(6):778.
doi: 10.3390/ani12060778.

Inflammatory Response and Electrocardiographic Examination in Horses Vaccinated against Equine Herpesvirus (Ehv-1)

Vito Biondi  1 , Alessandra Landi  2 , Michela Pugliese  1 , Giordana Merola  1 , Annamaria Passantino  1
Affiliations

Inflammatory Response and Electrocardiographic Examination in Horses Vaccinated against Equine Herpesvirus (Ehv-1)

Vito Biondi et al. Animals (Basel). .

Abstract

This study aimed to evaluate possible abnormalities in electrocardiographic findings, and changes in cardiac troponin I (cTnI) and inflammatory biomarkers (serum amyloid A (SAA) and C-reactive protein (CRP)) after inactivated herpesvirus vaccine administration. Eighteen healthy horses were included. All animals were vaccinated with Pneumoequine® (Merial, France) according to the protocol provided by the manufacturer. They were evaluated 1 day before the first dose of vaccination (D0), and 7 days (D1) and 14 days (D2) afterwards. At D0, D1, and D2, a blood sample was taken for the evaluation of SAA, cTnI, and CRP. An electrocardiographic examination was also performed. The data obtained suggested the possible involvement of the myocardium following vaccination against herpesvirus 1, mostly related to an inflammatory response.

Keywords: C-reactive protein; arrhythmias; cardiac troponin I; equine herpesvirus; serum amyloid A.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Davison A.J. Evolution of the herpesviruses. Vet. Microbiol. 2002;86:69–88. doi: 10.1016/S0378-1135(01)00492-8. - DOI - PubMed
    1. Allen G.P., Kydd J.H., Slater J.D., Smith K.C. Equid herpesvirus 1 and equid herpesvirus 4 infections. Infect. Dis. Livest. 2004;2:829–859.
    1. Davison A.J., Eberle R., Ehlers B., Hayward G.S., McGeoch D.J., Minson A.C., Pellett P.E., Roizman B., Studdert M.J., Thiry E. The order Herpesvirales. Arch. Virol. 2009;154:171–177. doi: 10.1007/s00705-008-0278-4. - DOI - PMC - PubMed
    1. Oladunni F.S., Horohov D.W., Chambers T.M. EHV-1: A Constant Threat to the Horse Industry. Front. Microbiol. 2019;10:2668. doi: 10.3389/fmicb.2019.02668. - DOI - PMC - PubMed
    1. Vandekerckhove A.P., Glorieux S., Gryspeerdt A.C., Steukers L., Van Doorsselaere J., Osterrieder N., Van de Walle G.R., Nauwynck H.J. Equine alphaherpesviruses (EHV-1 and EHV-4) differ in their efficiency to infect mononuclear cells during early steps of infection in nasal mucosal explants. Vet. Microbiol. 2011;152:21–28. doi: 10.1016/j.vetmic.2011.03.038. - DOI - PubMed