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. 1986 Aug;18(5-6):508-11.
doi: 10.1007/BF01964955.

Immunohistochemical evidence for mast cells containing 5-hydroxytryptamine in rat portal vein

F Barja, R Mathison, C Kursner

Immunohistochemical evidence for mast cells containing 5-hydroxytryptamine in rat portal vein

F Barja et al. Agents Actions. 1986 Aug.

Abstract

Serotonin was localized to mast cells in the adventitia of the rat portal vein by indirect immunohistochemistry. The mastocytes where preferentially localized to a region delimited by the pyloric and splenic veins. Since neither 48/80 nor reaginic antibody induced a significant change in the intrinsic spontaneous activity of the portal vein it would appear that the mast cells are not involved in a direct vasomotor function. It is suggested that amines released from the mastocytes could regulate blood flow in the vasa vasorum and/or have a role associated with the sensory functions displayed by this vein.

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