Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 6;10(3):612.
doi: 10.3390/biomedicines10030612.

Association of Neuropathic Pain Symptoms with Sensitization Related Symptomatology in Women with Fibromyalgia

Edurne Úbeda-D'Ocasar  1 , Juan Antonio Valera-Calero  1   2 , Gracia María Gallego-Sendarrubias  1 , César Fernández-de-Las-Peñas  3   4 , José Luis Arias-Buría  3 , Matilde Morales-Cabezas  3 , Lars Arendt-Nielsen  4   5 , Margarita Cigarán-Méndez  6
Affiliations

Association of Neuropathic Pain Symptoms with Sensitization Related Symptomatology in Women with Fibromyalgia

Edurne Úbeda-D'Ocasar et al. Biomedicines. .

Abstract

We aimed to analyze potential correlations between S-LANSS and PainDETECT with proxies for pain sensitization, e.g., the Central Sensitization Inventory (CSI) and pressure pain hyperalgesia (construct validity), pain-related or psychological variables (concurrent validity) in women with fibromyalgia (FMS). One-hundred-and-twenty-six females with FMS completed demographic, pain-related variables, psychological, and sensitization outcomes as well as the S-LANSS and the PainDETECT questionnaires. S-LANSS was positively associated with BMI (r = 0.206), pain intensity (r = 0.206 to 0.298) and CSI score (r = 0.336) and negatively associated with all PPTs (r = -0.180 to -0.336). PainDETECT was negatively associated with age (r = -0.272) and all PPTs (r = -0.226 to -0.378) and positively correlated with pain intensity (r = 0.258 to 0.439), CSI (r = 0.538), anxiety (r = 0.246) and depression (r = 0.258). 51.4% of the S-LANSS was explained by PainDETECT (45.3%), posterior iliac PPT (0.2%) and mastoid PPT (5.9%), whereas the 56.4% of PainDETECT was explained by S-LANSS (43.4%), CSI (10.4%), and pain intensity (2.6%). This study found good convergent association between S-LANSS and PainDETECT in women with FMS. Additionally, S-LANSS was associated with PPTs whereas PainDETECT was associated with pain intensity and CSI, suggesting that both questionnaires assess different spectrums of the neuropathic and pain sensitization components of a condition and hence provide synergistic information.

Keywords: chronic pain; fibromyalgia; neuropathic pain; pressure threshold; sensitization.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Scatter plot of the adjusted predicted score (r2 adjusted: 0.514) explaining the self-reported Leeds Assessment of Neuropathic Symptoms (S-LANSS) in women with fibromyalgia (n = 126). Note that some points can be overlapping.
Figure 2
Figure 2
Scatter plot of the adjusted predicted score (r2 adjusted: 0.564) explaining the PainDETECT score in women with fibromyalgia (n = 126). Note that some points can be overlapping.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Marques A.P., Santo A.D.S.D.E., Berssaneti A.A., Matsutani L.A., Yuan S.L.K. Prevalence of fibromyalgia: Literature review update. Rev. Bras. Reumatol. Engl. Ed. 2017;57:356–363. doi: 10.1016/j.rbr.2016.10.004. - DOI - PubMed
    1. Sumpton J.E., Moulin D.E. Fibromyalgia. Handb. Clin. Neurol. 2014;119:513–527. - PubMed
    1. Boomershine C.S. Fibromyalgia: The prototypical central sensitivity syndrome. Curr. Rheumatol. Rev. 2015;11:131–145. doi: 10.2174/1573397111666150619095007. - DOI - PubMed
    1. Siracusa R., Paola R., Cuzzocrea S., Impellizzeri D. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int. J. Mol. Sci. 2021;22:3891. doi: 10.3390/ijms22083891. - DOI - PMC - PubMed
    1. Cagnie B., Coppieters I., Denecker S., Six J., Danneels L., Meeus M. Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI. Semin. Arthritis Rheum. 2014;44:68–75. doi: 10.1016/j.semarthrit.2014.01.001. - DOI - PubMed

LinkOut - more resources