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. 2022 Mar 11;13(3):499.
doi: 10.3390/genes13030499.

Characterization of PCLO Gene in Amazonian Native American Populations

Amanda de Nazaré Cohen-Paes  1   2 , Darlen Cardoso de Carvalho  1 , Lucas Favacho Pastana  1   2 , Elizabeth Ayres Fragoso Dobbin  1   2 , Fabiano Cordeiro Moreira  1   2 , Tatiane Piedade de Souza  2 , Marianne Rodrigues Fernandes  1   2 , Diana Feio da Veiga Borges Leal  1   2 , Roberta Borges Andrade de Sá  1   2 , Angélica Leite de Alcântara  1   2 , João Farias Guerreiro  2 , Ândrea Ribeiro-Dos-Santos  1   2 , Sidney Emanuel Batista Dos Santos  1   2 , Paulo Pimentel de Assumpção  1 , Ney Pereira Carneiro Dos Santos  1   2
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Characterization of PCLO Gene in Amazonian Native American Populations

Amanda de Nazaré Cohen-Paes et al. Genes (Basel). .

Abstract

Genetic variations in PCLO have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We investigated 18 genetic variants in the PCLO gene in Amazonian indigenous and compared our results with the ones found in global populations, which were publicly available in the 1000 Genomes Project, gnmAD and ABraOM databases. The results demonstrated that the variants of the PCLO, especially rs17156844, rs550369696, rs61741659 and rs2877, have a significantly higher frequency in Amerindian populations in comparison with other continental populations. These data outline the singular genetic profile of the Native American population from the Brazilian Amazon region.

Keywords: Brazil; Native American; PCLO; genetic variants; indigenous populations.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Discriminant Analysis of Principal Components of PCLO gene in Native American populations and individuals Europe, East Asia, Americas, South Asia and Africa. Native American population (NAT), African population (AFR), European population (EUR), American population (AMR), East Asian population (EAS) and South Asian population (SAS).
See this image and copyright information in PMC

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