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. 1986 Sep;124(3):367-72.

The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin

M I Cybulsky, I G Colditz, H Z Movat

The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin

M I Cybulsky et al. Am J Pathol. 1986 Sep.

Abstract

Chemotactic factors induce neutrophil emigration into tissues. Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin. Kinetic studies revealed a rapid and transient neutrophil influx, with the peak rate at 30-90 minutes. Cross tachyphylaxis was observed between IL-1 and endotoxin; and this, together with its high potency and rapid onset of action, suggest that IL-1 mediates endotoxin-induced neutrophil emigration.

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