Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Sep;124(3):367-72.

The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin

M I Cybulsky, I G Colditz, H Z Movat

The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin

M I Cybulsky et al. Am J Pathol. 1986 Sep.

Abstract

Chemotactic factors induce neutrophil emigration into tissues. Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin. Kinetic studies revealed a rapid and transient neutrophil influx, with the peak rate at 30-90 minutes. Cross tachyphylaxis was observed between IL-1 and endotoxin; and this, together with its high potency and rapid onset of action, suggest that IL-1 mediates endotoxin-induced neutrophil emigration.

PubMed Disclaimer

References

    1. J Exp Med. 1973 May 1;137(5):1263-74 - PubMed
    1. Am J Pathol. 1986 Jul;124(1):1-9 - PubMed
    1. Lab Invest. 1980 Mar;42(3):310-7 - PubMed
    1. Infect Immun. 1982 May;36(2):558-66 - PubMed
    1. Exp Lung Res. 1982 Dec;4(1):47-66 - PubMed

Publication types

LinkOut - more resources