Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Mar 8;12(3):655.
doi: 10.3390/diagnostics12030655.

COVID-19 Infection Complicated by Disseminated Intravascular Coagulation during Pregnancy-Two Cases Report

Małgorzata Skalska-Świstek  1 , Hubert Huras  1 , Andrzej Piotr Jaworowski  1 , Rafał Świstek  2 , Magdalena Kołak  1
Affiliations
Case Reports

COVID-19 Infection Complicated by Disseminated Intravascular Coagulation during Pregnancy-Two Cases Report

Małgorzata Skalska-Świstek et al. Diagnostics (Basel). .

Abstract

Coagulopathies are one of the obstetric complications affecting the period of pregnancy, childbirth, and puerperium. One of the more severe and complex disorders of the haemostatic system is the disseminated intravascular coagulation syndrome (DIC), in which generalised activation of the coagulation system and activation of inflammatory cells occurs. DIC syndrome was observed in patients whose pregnancy was complicated by SARS-CoV-2 infection. Both the course of these cases and literature review indicate that particular notice should be paid to laboratory parameters of the coagulation system, closely monitoring the well-being of the foetus and, in the situation of acute DIC development, it is advised to deliver a baby and initiate intensive therapy.

Keywords: COVID-19; DIC; SARS-CoV-2; childbirth; coagulopathies; disseminated intravascular coagulation syndrome; pregnancy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Cardiotocography recording in a patient 1—normal baseline, reduced variability.
Figure 2
Figure 2
Histopatological images. Arrow—small infarcts.
Figure 3
Figure 3
Histopatological images. Arrow—fibrin deposits.
Figure 4
Figure 4
Chest Computed Tomography (HRCT).
Figure 5
Figure 5
Chest Computed Tomography (HRCT).
Figure 6
Figure 6
Cardiotocographic record made on day 0 of hospitalisation-normal baseline, normal variability.
Figure 7
Figure 7
CTG record on day 2 of hospitalisation. Tachycardia, decelerations.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lester E.P., Roth D.G. Disseminated intravascular coagulation in pregnancy. J. Reprod. Med. 1977;19:223–232. - PubMed
    1. Brenner B. Haemostatic changes in pregnancy. Thromb. Res. 2004;114:409–414. doi: 10.1016/j.thromres.2004.08.004. - DOI - PubMed
    1. Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin. Thromb. Hemost. 2003;29:125–130. doi: 10.1055/s-2003-38897. - DOI - PubMed
    1. Gando S., Levi M., Toh C.H. Disseminated intravascular coagulation. Nat. Rev. Dis. Primers. 2016;2:16037. doi: 10.1038/nrdp.2016.37. - DOI - PubMed
    1. Costello R.A., Nehring S.M. Disseminated Intravascular Coagulation. StatPearls Publishing; Treasure Island, FL, USA: 2022. - PubMed

Publication types

LinkOut - more resources