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. 2022 Mar 18;12(3):737.
doi: 10.3390/diagnostics12030737.

The Predicting Role of the Neutrophil-to-Lymphocyte Ratio for the Tumor Grade and Prognosis in Pancreatic Neuroendocrine Tumors

Dongwook Oh  1 , Jung-Soo Pyo  2 , Kwang Hyun Chung  3 , Byoung Kwan Son  3
Affiliations

The Predicting Role of the Neutrophil-to-Lymphocyte Ratio for the Tumor Grade and Prognosis in Pancreatic Neuroendocrine Tumors

Dongwook Oh et al. Diagnostics (Basel). .

Abstract

This study aims to investigate the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in pancreatic neuroendocrine tumors (PNETs) using meta-analysis. This study evaluates the correlation between the NLR and the prognosis in PNETs from nine eligible studies. In addition, a subgroup analysis based on the tumor grade, treatment, and evaluation criteria, was conducted. The estimated rate of a high NLR was 0.253 (95% confidence interval (CI) 0.198-0.317). The rate of high NLRs was significantly lower in patients with lower tumor grades (G1) than those with higher tumor grades (G2 or G3). In addition, the mean value of the NLR was significantly lower in lower tumor grades than in higher tumor grades. High NLRs were significantly correlated with worse overall and recurrence-free survivals (hazard ratio (HR) 2.180, 95% CI 1.499-3.169 and HR 2.462, 95% CI 1.677-3.615, respectively). In a subgroup analysis, the prognostic implications of the NLR were found in both higher and lower criteria of a high NLR. Taken together, our results show that the NLR could be useful for predicting the tumor grade and the prognosis in PNETs.

Keywords: biomarkers; inflammation mediators; meta-analysis; pancreatic neuroendocrine tumor; prognosis; tumor grade.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the literature search and selection methods.
Figure 2
Figure 2
Forest plots for the correlations between a high neutrophil-to-lymphocyte ratio and worse survival rates. (A) Overall survival and (B) recurrence-free survival.
See this image and copyright information in PMC

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