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Review
. 2022 Mar 15;23(6):3141.
doi: 10.3390/ijms23063141.

The Effect of Antioxidant Added to Preservation Solution on the Protection of Kidneys before Transplantation

Aneta Ostróżka-Cieślik  1
Affiliations
Review

The Effect of Antioxidant Added to Preservation Solution on the Protection of Kidneys before Transplantation

Aneta Ostróżka-Cieślik. Int J Mol Sci. .

Abstract

Ischemia-reperfusion injury is a key clinical problem of transplantology. Current achievements in optimizing organ rinse solutions and storage techniques have significantly influenced the degree of graft damage and its survival after transplantation. In recent years, intensive research has been carried out to maintain the viability of tissues and organs outside the integral environment of the body. Innovative solutions for improving the biochemical functions of the stored organ have been developed. The article discusses directions for modifying preservation solutions with antioxidants. Clinical and experimental studies aimed at optimizing these fluids, as well as perfusion and organ preservation techniques, are presented.

Keywords: antioxidants; organ preservation solution; renal transplantation.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Processes involved in kidney storage, ischemic damage, and antioxidant protection.
See this image and copyright information in PMC

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