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. 2022 Mar 11;19(6):3311.
doi: 10.3390/ijerph19063311.

The Effects of Action Observation Therapy as a Rehabilitation Tool in Parkinson's Disease Patients: A Systematic Review

Ioannis Giannakopoulos  1 , Panagiota Karanika  1 , Charalambos Papaxanthis  1   2   3 , Panagiotis Tsaklis  1   4
Affiliations

The Effects of Action Observation Therapy as a Rehabilitation Tool in Parkinson's Disease Patients: A Systematic Review

Ioannis Giannakopoulos et al. Int J Environ Res Public Health. .

Abstract

During Action Observation (AO), patients observe human movements that they then try to imitate physically. Until now, few studies have investigated the effectiveness of it in Parkinson's disease (PD). However, due to the diversity of interventions, it is unclear how the dose and characteristics can affect its efficiency. We investigated the AO protocols used in PD, by discussing the intervention features and the outcome measures in relation to their efficacy. A search was conducted through MEDLINE, Scopus, Cochrane, and WoS until November 2021, for RCTs with AO interventions. Participant's characteristics, treatment features, outcome measures, and main results were extracted from each study. Results were gathered into a quantitative synthesis (MD and 95% CI) for each time point. Seven studies were included in the review, with 227 participants and a mean PEDro score of 6.7. These studies reported positive effects of AO in PD patients, mainly on walking ability and typical motor signs of PD like freezing of gait. However, disagreements among authors exist, mainly due to the heterogeneity of the intervention features. In overall, AO improves functional abilities and motor control in PD patients, with the intervention dose and the characteristics of the stimulus playing a decisive role in its efficacy.

Keywords: Parkinson’s disease; action observation; mirror neurons; motor control; neurological rehabilitation; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart diagram of the study selection process. **, irrelevant records excluded.
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References

    1. Gallese V., Fadiga L., Fogassi L., Rizzolatti G. Action recognition in the premotor cortex. Brain. 1996;119:593–609. doi: 10.1093/brain/119.2.593. - DOI - PubMed
    1. Rizzolatti G., Fadiga L., Gallese V., Fogassi L. Premotor cortex and the recognition of motor actions. Brain Res. Cogn. Brain Res. 1996;3:131–141. doi: 10.1016/0926-6410(95)00038-0. - DOI - PubMed
    1. Hari R., Forss N., Avikainen S., Kirveskari E., Salenius S., Rizzolatti G. Activation of human primary motor cortex during action observation: A neuromagnetic study. Proc. Natl. Acad. Sci. USA. 1998;95:15061–15065. doi: 10.1073/pnas.95.25.15061. - DOI - PMC - PubMed
    1. Fabbri-Destro M., Rizzolatti G. Mirror neurons and mirror systems in monkeys and humans. Physiology. 2008;23:171–179. doi: 10.1152/physiol.00004.2008. - DOI - PubMed
    1. Fadiga L., Fogassi L., Pavesi G., Rizzolatti G. Motor facilitation during action observation: A magnetic stimulation study. J. Neurophysiol. 1995;73:2608–2611. doi: 10.1152/jn.1995.73.6.2608. - DOI - PubMed

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