Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 18;19(6):3627.
doi: 10.3390/ijerph19063627.

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Glaucia Schuindt Teixeira Neves  1   2 , Gayathiri Elangovan  3 , Mayla Kezy Silva Teixeira  1 , João Martins de Mello-Neto  3 , Santosh Kumar Tadakamadla  3   4 , Eduardo José Veras Lourenço  1 , Daniel Moraes Telles  1 , Carlos Marcelo Figueredo  3   5
Affiliations

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Glaucia Schuindt Teixeira Neves et al. Int J Environ Res Public Health. .

Abstract

sTREM-1 and its ligand PGLYRP1 play an essential role in the inflammatory process around teeth and implants. In this study, we aimed to evaluate the impact of peri-implant treatment on the salivary levels of the sTREM-1/PGLYRP-1/MMP-8 axis after 3 months. A total of 42 participants (with a mean age of 61 years old ± 7.3) were enrolled in this longitudinal study, 24 having peri-implant mucositis (MU) and 18 having peri-implantitis (PI). Clinical peri-implant parameters, such as probing pocket depth (PPD), % of plaque, and bleeding on probing (BOP), and the whole unstimulated saliva samples were evaluated at baseline and 3 months after treatment. The MU group received nonsurgical peri-implant treatment, while the PI group received open-flap procedures. The levels of sTREM-1, PGLYRP-1, MMP-8, and TIMP-1 were analyzed using enzyme-linked immunosorbent assays. BOP, plaque levels, and PPD significantly reduced after treatment in both groups. A significant decrease in the salivary levels of sTREM-1, MMP-8, and TIMP-1 in the PI group and PGLYRP1 and TIMP-1 in the MU group were observed. Salivary levels of sTREM-1 were significantly reduced in patients with PI but not with MU. Additionally, peri-implant treatment had a significantly higher impact on MMP-8 reduction in patients with PI than in those with MU.

Keywords: MMP-8; PGLYRP-1; peri-implant mucositis; peri-implant treatment; peri-implantitis; sTREM-1.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Levels of sTREM-1, PGLYRP-1, MMP-8, and TIMP-1 in saliva from individuals with peri-implant mucositis and peri-implantitis before and after treatment. p ≤ 0.05 (Wilcoxon signed-rank test).
Figure 2
Figure 2
The treatment effect variation in salivary levels of sTREM-1, PGLYRP1, MMP-8, and TIMP-1 from peri-implant mucositis patients and peri-implantitis expressed in Δ. p ≤ 0.05 (Mann–Whitney U test).
Figure 3
Figure 3
Ratio comparisons of total sTREM-1/PGLYRP-1, sTREM-1/MMP-8, and MMP-8/TIMP-1 in peri-implant mucositis patients and peri-implantitis patients at baseline and after peri-implant treatment. p ≤ 0.05 (Mann–Whitney U test).
Figure 4
Figure 4
Peri-implant treatment effects on the ratio of total sTREM-1/PGLYRP-1, sTREM-1/MMP-8, and MMP-8/TIMP-1 in peri-implant mucositis patients and peri-implantitis patients before and after peri-implant treatment. p ≤ 0.05 (Wilcoxon signed-rank test).
Figure 5
Figure 5
Heat maps exhibit correlations between the biomarkers and clinical parameters (a) and biomarkers (b) in saliva. * R ≥ 0.6, p ≤ 0.01 (Spearman correlation). PD: probing depth; BOP: bleeding on probing.
See this image and copyright information in PMC

References

    1. Berglundh T., Armitage G., Araujo M.G., Avila-Ortiz G., Blanco J., Camargo P.M., Chen S., Cochran D., Derks J., Figuero E., et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Periodontol. 2018;89:S313–S318. doi: 10.1002/JPER.17-0739. - DOI - PubMed
    1. Heitz-Mayfield L.J.A., Salvi G.E. Peri-implant mucositis. J. Clin. Periodontol. 2018;45:S237–S245. doi: 10.1111/jcpe.12953. - DOI - PubMed
    1. Schwarz F., Derks J., Monje A., Wang H.L. Peri-implantitis. J. Clin. Periodontol. 2018;45:S246–S266. doi: 10.1111/jcpe.12954. - DOI - PubMed
    1. Derks J., Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J. Clin. Periodontol. 2015;42:S158–S171. doi: 10.1111/jcpe.12334. - DOI - PubMed
    1. Zhang H., Li W., Zhang L., Yan X., Shi D., Meng H. A nomogram prediction of peri-implantitis in treated severe periodontitis patients: A 1-5-year prospective cohort study. Clin. Implant. Dent. Relat. Res. 2018;20:962–968. doi: 10.1111/cid.12686. - DOI - PubMed

Publication types

MeSH terms

Substances