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Clinical Trial
. 1986 Aug;30(2):211-4.
doi: 10.1128/AAC.30.2.211.

Imipenem-cilastatin as initial therapy for febrile cancer patients

G P Bodey, M E Alvarez, P G Jones, K V Rolston, L Steelhammer, V Fainstein
Clinical Trial

Imipenem-cilastatin as initial therapy for febrile cancer patients

G P Bodey et al. Antimicrob Agents Chemother. 1986 Aug.

Abstract

Imipenem-cilastatin was used to treat 79 febrile episodes in 71 cancer patients, most of whom had neutropenia. The overall response rate was 67%, and 76% of the 45 documented infections responded. The response rates for septicemias and pneumonias were 79 and 62%, respectively. Only 1 of the 17 infections caused by gram-negative bacilli failed to respond to this therapy. The most common side effects were skin rash, nausea, and diarrhea. Eight superinfections were detected during therapy.

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