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. 2022 Mar 15;15(6):2176.
doi: 10.3390/ma15062176.

Adsorption of Inositol Phosphate on Hydroxyapatite Powder with High Specific Surface Area

Hirogo Minamisawa  1 , Yoshiyuki Kojima  2 , Mamoru Aizawa  3
Affiliations

Adsorption of Inositol Phosphate on Hydroxyapatite Powder with High Specific Surface Area

Hirogo Minamisawa et al. Materials (Basel). .

Abstract

Chelate-setting calcium-phosphate cements (CPCs) have been developed using inositol phosphate (IP6) as a chelating agent. However, the compressive strength of the CPC fabricated from a commercially available hydroxyapatite (HAp) powder was approximately 10 MPa. In this study, we miniaturized HAp particles as a starting powder to improve the compressive strength of chelate-setting CPCs and examined the adsorption properties of IP6 onto HAp powders. An HAp powder with a specific surface area (SSA) higher than 200 m2/g (HApHS) was obtained by ultrasonic irradiation for 1 min in a wet synthesis process, greatly improving the SSA (214 m2/g) of the commercial powder without ultrasonic irradiation. The HApHS powder was found to be a B-type carbonate-containing HAp in which the phosphate groups in apatite were replaced by carbonate groups. Owing to the high SSA, the HApHS powder also showed high IP6 adsorption capacity. The adsorption phenomena of IP6 to our HApHS and commercially available Hap powders were found to follow the Freundlich and Langmuir models, respectively. We found that IP6 adsorbs on the HApHS powder by both physisorption and chemisorption. The fine HapHS powder with a high SSA is a novel raw powder material, expected to improve the compressive strength of chelate-setting CPCs.

Keywords: Hydroxyapatite; adsorption; chelate-setting cement; inositol phosphate; ultrasonic irradiation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Median diameters of Ca(OH)2 powder after ultrasonic irradiation for different durations (error bars: ± S.D., n = 3).
Figure 2
Figure 2
X-ray diffraction patterns of HApHS(X) powder after ultrasonic irradiation. (X: 0–5 min), (a) HApHS(0), (b) HApHS(1), (c) HApHS(2), (d) HApHS(3), (e) HApHS(4), (f) HApHS(5). 〇: HAp.
Figure 3
Figure 3
Fourier-transform infrared spectra of HApHS(X) powder after ultrasonic irradiation. (X: 0–5 min), (a) HApHS(0), (b) HApHS(1), (c) HApHS(2), (d) HApHS(3), (e) HApHS(4), (f) HApHS(5).
Figure 4
Figure 4
TEM images of (a) HApHS(0) and (b) HApHS(1) powders.
Figure 5
Figure 5
Optimization of shaking time for IP6 adsorption (error bars: ± S.D., n = 3) by (a) HApHS powder (●) and (b) HAp powder (■).
Figure 6
Figure 6
X-ray diffraction patterns of (A) HAp and (B) HApHS powder after adsorbing IP6. Initial concentrations of IP6 solution (mg/cm3): (a) 0, (b) 100, (c) 500, (d) 1000, (e) 2500, (f) 5000, (g) 10,000. 〇: HAp.
Figure 7
Figure 7
Adsorption isotherms of IP6 for different HAp surface (error bars: ±S.D., n = 3): (a) HapHS powder (●) and (b) HAp powder (■).
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