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Review
. 2022 Mar 16;15(6):2194.
doi: 10.3390/ma15062194.

Bioactive Glasses in Periodontal Regeneration: Existing Strategies and Future Prospects-A Literature Review

Valeria Cannillo  1 , Roberta Salvatori  2 , Stefania Bergamini  3 , Devis Bellucci  1 , Carlo Bertoldi  3
Affiliations
Review

Bioactive Glasses in Periodontal Regeneration: Existing Strategies and Future Prospects-A Literature Review

Valeria Cannillo et al. Materials (Basel). .

Abstract

The present review deals with bioactive glasses (BGs), a class of biomaterials renowned for their osteoinductive and osteoconductive capabilities, and thus widely used in tissue engineering, i.e., for the repair and replacement of damaged or missing bone. In particular, the paper deals with applications in periodontal regeneration, with a special focus on in vitro, in vivo and clinical studies. The study reviewed eligible publications, identified on the basis of inclusion/exclusion criteria, over a ranged time of fifteen years (from 1 January 2006 to 31 March 2021). While there are many papers dealing with in vitro tests, only a few have reported in vivo (in animal) research, or even clinical trials. Regardless, BGs seem to be an adequate choice as grafts in periodontal regeneration.

Keywords: animal model; bioactive glasses; bone regeneration; clinical trials; coatings; in vitro tests; in vivo tests; periodontal regeneration; scaffolds.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
BGs use as regenerative surgical treatment in dentistry.
Figure 2
Figure 2
Schematic illustration of the BGs effect on periodontal cells.
Figure 3
Figure 3
Articles distribution in clinical/in vitro/in vivo studies in periodontal regeneration with BGs, from 2006 to 2021.
Figure 4
Figure 4
Different types of BGs used in clinical studies in periodontal patients from 2006 to 2021.
Figure 5
Figure 5
Flow diagram of the included articles.
See this image and copyright information in PMC

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