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. 2022 Mar 8;11(6):1476.
doi: 10.3390/jcm11061476.

The Future of Adhesion Prophylaxis Trials in Abdominal Surgery: An Expert Global Consensus

Rudy Leon De Wilde  1 , Rajesh Devassy  2 , Richard P G Ten Broek  3 , Charles E Miller  4 , Aizura Adlan  5 , Prudence Aquino  6 , Sven Becker  7 , Ferry Darmawan  8 , Marco Gergolet  9 , Maria Antonia E Habana  10 , Chong Kiat Khoo  11 , Philippe R Koninckx  12 , Matthias Korell  13 , Harald Krentel  14 , Olarik Musigavong  15 , George Pistofidis  16 , Shailesh Puntambekar  17 , Ichnandy A Rachman  18 , Fatih Sendag  19 , Markus Wallwiener  20 , Luz Angela Torres-de la Roche  1
Affiliations

The Future of Adhesion Prophylaxis Trials in Abdominal Surgery: An Expert Global Consensus

Rudy Leon De Wilde et al. J Clin Med. .

Abstract

Postoperative adhesions represent a frequent complication of abdominal surgery. Adhesions can result from infection, ischemia, and foreign body reaction, but commonly develop after any surgical procedure. The morbidity caused by adhesions affects quality of life and, therefore, it is paramount to continue to raise awareness and scientific recognition of the burden of adhesions in healthcare and clinical research. This 2021 Global Expert Consensus Group worked together to produce consented statements to guide future clinical research trials and advise regulatory authorities. It is critical to harmonize the expectations of research, to both develop and bring to market improved anti-adhesion therapies, with the ultimate, shared goal of improved patient outcomes.

Keywords: adhesion; antiadhesion agent; consensus; minimally invasive surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
History of adhesion preventing drugs and device development.
Figure 2
Figure 2
Pathogenesis of adhesion formation. Reproduced with permission from: De Wilde, R.L., Trew, G. & on behalf of the Expert Adhesions Working Party of the European Society of Gynaecological Endoscopy (ESGE) [5].
Figure 3
Figure 3
Computationally estimated visceral slide on CineMRI along the contour of the peritoneal cavity. The red mask is the output of a deep learning system that segments the peritoneal cavity, the red boxes show the reference annotations by a radiologist. Low visceral slide (blue) corresponds to locations suspicious for adhesions. Figure adapted from https://github.com/DIAGNijmegen/adhesion_detection, accessed on 8 February 2022.
See this image and copyright information in PMC

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