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Review
. 2022 Mar 9;11(6):1498.
doi: 10.3390/jcm11061498.

Role of New Anatomy, Biliopancreatic Reflux, and Helicobacter Pylori Status in Postgastrectomy Stump Cancer

Luigi Basso  1 , Gaetano Gallo  2 , Daniele Biacchi  1 , Maria Vittoria Carati  1 , Giuseppe Cavallaro  1 , Luca Esposito  1 , Andrea Giuliani  1 , Luciano Izzo  1 , Paolo Izzo  1 , Antonietta Lamazza  1 , Andrea Polistena  1 , Mariarita Tarallo  1 , Alessandro Micarelli  3   4 , Enrico Fiori  1
Affiliations
Review

Role of New Anatomy, Biliopancreatic Reflux, and Helicobacter Pylori Status in Postgastrectomy Stump Cancer

Luigi Basso et al. J Clin Med. .

Abstract

Distal gastrectomy for benign gastroduodenal peptic disease has become rare, but it still represents a widely adopted procedure for advanced and, in some countries, even for early distal gastric cancer. Survival rates following surgery for gastric malignancy are constantly improving, hence the residual mucosa of the gastric stump is exposed for a prolonged period to biliopancreatic reflux and, possibly, to Helicobacter pylori (HP) infection. Biliopancreatic reflux and HP infection are considered responsible for gastritis and metachronous carcinoma in the gastric stump after oncologic surgery. For gastrectomy patients, in addition to eradication treatment for cases that are already HP positive, endoscopic surveillance should also be recommended, for prompt surveillance and detection in the residual mucosa of any metaplastic-atrophic-dysplastic features following surgery.

Keywords: Helicobacter pylori infection; biliopancreatic reflux; carcinoma; endoscopic surveillance; gastric cancer; gastric stump cancer; gastritis.

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Conflict of interest statement

The authors declare no conflict of interest.

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