Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 10;11(6):1526.
doi: 10.3390/jcm11061526.

Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer's Disease

Min Seok Baek  1 , Narae Lee  2 , Jin Woo Kim  3 , Jin Yong Hong  1
Affiliations

Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer's Disease

Min Seok Baek et al. J Clin Med. .

Abstract

We investigated the relationship between hippocampal subfield volumes and cortical amyloid-beta (Aβ) deposition in Alzheimer’s disease (AD). Fifty participants (11 cognitively unimpaired [CU], 10 with mild cognitive impairment [MCI], and 29 with AD) who underwent 18F-florbetaben positron emission tomography, magnetic resonance imaging, and neuropsychological tests were enrolled. The hippocampal subfield volumes were obtained using an automated brain volumetry system with the Winterburn atlas and were compared among the diagnostic groups, and the correlations with the Aβ deposition and AD risk factors were determined. Patients with MCI and AD showed decreased volume in the stratum radiatum/lacunosum/moleculare (SRLM) of the cornu ammonis (CA)1 and CA4-dentate gyrus (DG) compared with the CU. Decreased SRLM and CA4-DG volumes were associated with an increased Aβ deposition in the global cortex (R = −0.459, p = 0.001; R = −0.393, p = 0.005, respectively). The SRLM and CA4-DG volumes aided in the distinction of AD from CU (areas under the receiver operating characteristic [AUROC] curve = 0.994 and 0.981, respectively, p < 0.001), and Aβ+ from Aβ− individuals (AUROC curve = 0.949 and 0.958, respectively, p < 0.001). Hippocampal subfield volumes demonstrated potential as imaging biomarkers in the diagnosis and detection of AD and Aβ deposition, respectively.

Keywords: Alzheimer’s disease; amyloid-beta; biomarker; hippocampal subfields.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
An example of hippocampal subfield segmentation in the HIPS pipeline. (A) Axial, (B) Coronal, and (C) Sagittal sections. Abbreviations: CA = cornu ammonis, DG = dentate gyrus, SRLM = stratum radiatum/lacunosum/moleculare.
Figure 2
Figure 2
Between-group comparisons of the hippocampal subfield volumes. (A) Total hippocampal volume, (B) CA1, (C) CA2–3, (D) CA4-DG, (E) SRLM, (F) subiculum. Abbreviations: AD = Alzheimer’s disease, CU = cognitively unimpaired, MCI = mild cognitive impairment, CA = cornu ammonis, SRLM = stratum radiatum/lacunosum/moleculare.
Figure 3
Figure 3
Receiver operating characteristic (ROC) curves of the hippocampal subfield volumes. (A) AD from CU (B) Aβ+ vs. Aβ−. Abbreviations: CU = cognitively unimpaired, AD = Alzheimer’s disease, Aβ = Amyloid-β, Total Hippo = whole hippocampus volume.
See this image and copyright information in PMC

References

    1. Eichenbaum H., Sauvage M., Fortin N., Komorowski R., Lipton P. Towards a functional organization of episodic memory in the medial temporal lobe. Neurosci. Biobehav. Rev. 2012;36:1597–1608. doi: 10.1016/j.neubiorev.2011.07.006. - DOI - PMC - PubMed
    1. Battaglia F.P., Benchenane K., Sirota A., Pennartz C.M., Wiener S.I. The hippocampus: Hub of brain network communication for memory. Trends Cogn. Sci. 2011;15:310–318. doi: 10.1016/j.tics.2011.05.008. - DOI - PubMed
    1. Jack C.R., Jr., Lowe V.J., Senjem M.L., Weigand S.D., Kemp B.J., Shiung M.M., Knopman D.S., Boeve B.F., Klunk W.E., Mathis C.A. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment. Brain. 2008;131:665–680. doi: 10.1093/brain/awm336. - DOI - PMC - PubMed
    1. Jack C.R., Wiste H.J., Vemuri P., Weigand S.D., Senjem M.L., Zeng G.A., Bernstein M.A., Gunter J.L., Pankratz V.S., Aisen P.S., et al. Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer’s disease. Brain. 2010;133:3336–3348. doi: 10.1093/brain/awq277. - DOI - PMC - PubMed
    1. Cardenas V.A., Chao L.L., Studholme C., Yaffe K., Miller B.L., Madison C., Buckley S.T., Mungas D., Schuff N., Weiner M.W. Brain atrophy associated with baseline and longitudinal measures of cognition. Neurobiol. Aging. 2011;32:572–580. doi: 10.1016/j.neurobiolaging.2009.04.011. - DOI - PMC - PubMed

LinkOut - more resources