Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 15;11(6):1617.
doi: 10.3390/jcm11061617.

Dietary Patterns and Their Associations with Intermediate Age-Related Macular Degeneration in a Japanese Population

Mariko Sasaki  1   2   3 , Naoko Miyagawa  4 , Sei Harada  4 , Kazuo Tsubota  1 , Toru Takebayashi  4 , Yuji Nishiwaki  5 , Ryo Kawasaki  6
Affiliations

Dietary Patterns and Their Associations with Intermediate Age-Related Macular Degeneration in a Japanese Population

Mariko Sasaki et al. J Clin Med. .

Abstract

This population-based cross-sectional study investigated the influence of dietary patterns on age-related macular degeneration (AMD) in a Japanese population. The Tsuruoka Metabolomics Cohort Study enrolled a general population aged 35-74 years from among participants in annual health check-up programs in Tsuruoka City, Japan. Eating habits were assessed using a food frequency questionnaire. Principal component analysis was used to identify dietary patterns among food items. The association between quartiles of scores for each dietary pattern and intermediate AMD was assessed using multivariate logistic regression models. Of 3433 participants, 415 had intermediate AMD. We identified four principal components comprising the Vegetable-rich pattern, Varied staple food pattern, Animal-rich pattern, and Seafood-rich pattern. After adjusting for potential confounders, higher Varied staple food diet scores were associated with a lower prevalence of intermediate AMD (fourth vs. first quartile) (OR, 0.63; 95% confidence interval [CI], 0.46-0.86). A significant trend of decreasing ORs for intermediate AMD associated with increasing Varied staple food diet scores was noted (p for trend = 0.002). There was no significant association between the other dietary patterns and intermediate AMD. In a Japanese population, individuals with a dietary pattern score high in the Varied staple food pattern had a lower prevalence of intermediate AMD.

Keywords: Asian; age-related macular degeneration (AMD); dietary pattern; intermediate AMD; principal component analysis; staple food.

PubMed Disclaimer

Conflict of interest statement

None of the authors have any proprietary interests or conflicts of interest related to this submission.

Similar articles

See all similar articles

Cited by

  • Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS).
    Harada S, Iida M, Miyagawa N, Hirata A, Kuwabara K, Matsumoto M, Okamura T, Edagawa S, Kawada Y, Miyake A, Toki R, Akiyama M, Kawai A, Sugiyama D, Sato Y, Takemura R, Fukai K, Ishibashi Y, Kato S, Kurihara A, Sata M, Shibuki T, Takeuchi A, Kohsaka S, Sawano M, Shoji S, Izawa Y, Katsumata M, Oki K, Takahashi S, Takizawa T, Maruya H, Nishiwaki Y, Kawasaki R, Hirayama A, Ishikawa T, Saito R, Sato A, Soga T, Sugimoto M, Tomita M, Komaki S, Ohmomo H, Ono K, Otsuka-Yamasaki Y, Shimizu A, Sutoh Y, Hozawa A, Kinoshita K, Koshiba S, Kumada K, Ogishima S, Sakurai-Yageta M, Tamiya G, Takebayashi T. Harada S, et al. J Epidemiol. 2024 Aug 5;34(8):393-401. doi: 10.2188/jea.JE20230192. Epub 2024 Jun 30. J Epidemiol. 2024. PMID: 38191178 Free PMC article.

References

    1. Lim L.S., Mitchell P., Seddon J.M., Holz F.G., Wong T.Y. Age-related macular degeneration. Lancet. 2012;379:1728–1738. doi: 10.1016/S0140-6736(12)60282-7. - DOI - PubMed
    1. Kawasaki R., Yasuda M., Song S.J., Chen S.J., Jonas J.B., Wang J.J., Mitchell P., Wong T.Y. The prevalence of age-related macular degeneration in Asians: A systematic review and meta-analysis. Ophthalmology. 2010;117:921–927. doi: 10.1016/j.ophtha.2009.10.007. - DOI - PubMed
    1. Wong W.L., Su X., Li X., Cheung C.M., Klein R., Cheng C.Y., Wong T.Y. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis. Lancet Glob. Health. 2014;2:e106–e116. doi: 10.1016/S2214-109X(13)70145-1. - DOI - PubMed
    1. Seddon J.M., Ajani U.A., Sperduto R.D., Hiller R., Blair N., Burton T.C., Farber M.D., Gragoudas E.S., Haller J., Miller D.T., et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994;272:1413–1420. doi: 10.1001/jama.1994.03520180037032. - DOI - PubMed
    1. Mares-Perlman J.A., Fisher A.I., Klein R., Palta M., Block G., Millen A.E., Wright J.D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am. J. Epidemiol. 2001;153:424–432. doi: 10.1093/aje/153.5.424. - DOI - PubMed

LinkOut - more resources