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Review
. 2022 Mar 15;12(3):423.
doi: 10.3390/life12030423.

Metabolic Bone Disorders in Children with Inflammatory Bowel Diseases

Mariusz Olczyk  1 , Elżbieta Czkwianianc  2 , Anna Socha-Banasiak  2
Affiliations
Review

Metabolic Bone Disorders in Children with Inflammatory Bowel Diseases

Mariusz Olczyk et al. Life (Basel). .

Abstract

In recent years, there has been a noticeable increase in the incidence of inflammatory bowel diseases in the pediatric population. Entry observations demonstrate anemia, malabsorption, deficiencies in vitamin D and calcium. These aspects, together with the systemic action of pro-inflammatory cytokines and steroid therapy are widely recognized as factors influencing bone metabolism. Presently, however, there are very few studies that can be found in the scientific literature on metabolic disorders in patients with IBD, especially in the pediatric population as the coexistence has not been sufficiently examined and understood. This review aims to summarize the currently available literature, as well as assess which areas have information gaps and need further research.

Keywords: Crohn’s disease; IBD; bone mineral density; metabolic disorders; pediatrics; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potential pathways in the course of inflammatory bowel disease leading to metabolic bone disorders in children.
Figure 2
Figure 2
Effects of cytokines on osteoclast and osteoblast formation and bone resorption.
Figure 3
Figure 3
Activities and aspects that require special attention to minimize the risk of bone metabolism disorders in children.
See this image and copyright information in PMC

References

    1. Krzesiek E., Kofla-Dlubacz A., Akutko K., Stawarski A. The Incidence of Inflammatory Bowel Disease in the Paediatric Population in the District of Lower Silesia, Poland. J. Clin. Med. 2021;10:3994. doi: 10.3390/jcm10173994. - DOI - PMC - PubMed
    1. Langholz E., Munkholm P., Krasilnikoff P.A., Binder V. Inflammatory bowel diseases with onset in childhood. Clinical features, morbidity, and mortality in a regional cohort. Scand. J. Gastroenterol. 1997;32:139–147. doi: 10.3109/00365529709000184. - DOI - PubMed
    1. Mitchell P.J., Rabau M.Y., Haboubi N.Y. Indeterminate colitis. Technol. Coloproctol. 2007;11:91–96. doi: 10.1007/s10151-007-0337-y. - DOI - PubMed
    1. Ye Y., Manne S., Treem W.R., Bennett D. Prevalence of Inflammatory Bowel Disease in Pediatric and Adult Populations: Recent Estimates from Large National Databases in the United States, 2007–2016. Inflamm. Bowel Dis. 2020;26:619–625. doi: 10.1093/ibd/izz182. - DOI - PubMed
    1. Jevon G.P., Madhur R. Endoscopic and histologic findings in pediatric inflammatory bowel disease. Gastroenterol. Hepatol. 2010;6:174–180. - PMC - PubMed

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