Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 4;8(3):263.
doi: 10.3390/jof8030263.

Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan

Fateme Abedini  1 , Shahla Roudbar Mohammadi  2 , Mostafa Dahmardehei  3 , Marjan Ajami  4 , Maryam Salimi  5 , Halala Khalandi  6 , Monireh Mohsenzadegan  7 , Farhad Seif  8 , Bahador Nikoueian Shirvan  2 , Sanaz Yaalimadad  2 , Maryam Roudbary  6 , Célia F Rodrigues  9   10
Affiliations

Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan

Fateme Abedini et al. J Fungi (Basel). .

Abstract

The mortality and disability-adjusted life years (DALYs) of burn patients are decreasing over time. However, finding novel effective treatment approaches using natural agents is highly considered to reduce the burden of burn injuries. One of the recent agents used in wound healing is β-glucan, mainly extracted from fungi cell walls. This study aimed to evaluate the effect of 5% (m/m) of yeast β-glucan ointment on burn wound healing and to assess the impact of β-glucan on cytokines during the treatment. Thirty-three patients with second or third-degree burns were enrolled in this study. Two groups of twenty-three and ten patients used yeast 5% (m/m) β-glucan ointment (study group) and Stratamed ointment (control), respectively, on a daily basis, for a maximum of four weeks. The size of the burn wounds was measured before and at the end of the treatment. Blood samples of 14 and 10 patients in the β-glucan and control groups, respectively, were obtained before and after the treatment, and the enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum concentration of the IL-4, IL-17, and IFN-γ cytokines. The log-binomial model was used to assess the efficacy of the β-glucan ointment on burn wound healing. ANOVA/ANCOVA was employed to assess the effects of β-glucan on the serum concentration of cytokines. After adjusting for potential confounders/covariates, patients receiving β-glucan had better wound healing (RR = 4.34; 95% CI: 0.73 to 25.67; p = 0.11). There was a significant difference in IL-4 secretion between the β-glucan and control groups after adjusting for potential confounders/covariates (MD = 77.27; 95% CI: 44.73 to 109.82; Cohen's d = 2.21; 95% CI: 1.16 to 3.24; p = 0.0001). The results indicate that 5% (m/m) of β-glucan has efficacy in burn wound healing, and a significant difference was found in the level of IL-4 after receiving β-glucan. Further studies with a two-arm design and long-term use of ointment are needed to confirm the effect of β-glucan on wound healing and cytokine secretion.

Keywords: Candida albicans; burn patients; cytokine assay; ointment; wound healing; β-glucan.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflict of interest.

References

    1. James S.L., Lucchesi L.R., Bisignano C., Castle C.D., Dingels Z.V., Fox J.T., Hamilton E.B., Henry N.J., McCracken D., Roberts N.L.S., et al. Epidemiology of injuries from fire, heat and hot substances: Global, regional and national morbidity and mortality estimates from the Global Burden of Disease 2017 study. Inj. Prev. 2019;26((Suppl. 2)):i36–i45. doi: 10.1136/injuryprev-2019-043299. - DOI - PMC - PubMed
    1. Roshangar L., Soleimani Rad J., Kheirjou R., Reza Ranjkesh M., Ferdowsi Khosroshahi A. Skin Burns: Review of Molecular Mechanisms and Therapeutic Approaches. Wounds A Compend. Clin. Res. Pract. 2019;31:308–315. - PubMed
    1. Sanchez J.L., Bastida J.L., Martínez M.M., Moreno J.M., Chamorro J.J. Socio-economic cost and health-related quality of life of burn victims in Spain. Burn. J. Int. Soc. Burn Inj. 2008;34:975–981. doi: 10.1016/j.burns.2007.12.011. - DOI - PubMed
    1. Soltanian S., Stuyven E., Cox E., Sorgeloos P., Bossier P. Beta-glucans as immunostimulant in vertebrates and invertebrates. Crit. Rev. Microbiol. 2009;35:109–138. doi: 10.1080/10408410902753746. - DOI - PubMed
    1. Rahgozar M., Pazokitoroudi H., Bakhtiarian A., Djahanguiri B. Diazoxide, a KATP opener, accelerates restitution of ethanol or indomethacin-induced gastric ulceration in rats independent of polyamines. J. Gastroenterol. Hepatol. 2001;16:290–296. doi: 10.1046/j.1440-1746.2001.02433.x. - DOI - PubMed

LinkOut - more resources