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Review
. 2022 Mar 7;12(3):413.
doi: 10.3390/jpm12030413.

Searching for New Molecular Targets for Oral Squamous Cell Carcinoma with a View to Clinical Implementation of Precision Medicine

Tomonori Sasahira  1 , Miyako Kurihara-Shimomura  2 , Yudai Shimojjukoku  1 , Kaori Shima  1 , Tadaaki Kirita  2
Affiliations
Review

Searching for New Molecular Targets for Oral Squamous Cell Carcinoma with a View to Clinical Implementation of Precision Medicine

Tomonori Sasahira et al. J Pers Med. .

Abstract

Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the eighth most common malignancy globally and is characterized by local invasiveness and high nodal metastatic potential. The OSCC incidence is also increasing, and the number of deaths is also rising steadily in Japan. The development of molecular markers to eradicate OSCC is an urgent issue for humankind. The increase in OSCC despite the declining smoking rate may be due to several viral infections through various sexual activities and the involvement of previously unfocused carcinogens, and genetic alterations in individual patients are considered to be more complicated. Given this situation, it is difficult to combat OSCC with conventional radiotherapy and chemotherapy using cell-killing anticancer drugs alone, and the development of precision medicine, which aims to provide tailor-made medicine based on the genetic background of each patient, is gaining attention. In this review article, the current status of the comprehensive search for driver genes and biomarkers in OSCC will be briefly described, and some of the candidates for novel markers of OSCC that were found will be outlined.

Keywords: biomarker; oral squamous cell carcinoma; precision medicine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Shema of signaling pathways highly prevalent in head and neck cancer. The green and yellow columns represent HPV-negative and HPV-positive cancer predominance, respectively. Figure in [15] was modified.
Figure 2
Figure 2
Shema of TANGO-related signal.
Figure 3
Figure 3
Shema of LEMD1-associated signal.
See this image and copyright information in PMC

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References

    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Siegel R.L., Miller K.D., Fuchs H.E., Jemal A. Cancer statistics, 2022. CA Cancer J. Clin. 2022;72:7–33. doi: 10.3322/caac.21708. - DOI - PubMed
    1. Patil R., Mahajan A., Pradeep G.L., Prakash N., Patil S., Khan S.M. Expression of matrix metalloproteinase-9 in histological grades of oral squamous cell carcinoma: An immunohistochemical study. J. Oral Maxillofac. Pathol. 2021;25:239–246. - PMC - PubMed
    1. Rizzo J.D., Curtis R.E., Socié G., Sobocinski K.A., Gilbert E., Landgren O., Travis L.B., Travis W.D., Flowers M.E., Friedman D.L., et al. Solid cancers after allogeneic hematopoietic cell transplantation. Blood. 2009;113:1175–1183. doi: 10.1182/blood-2008-05-158782. - DOI - PMC - PubMed
    1. Hanahan D., Weinberg R.A. Hallmarks of cancer: The next generation. Cell. 2011;144:646–674. doi: 10.1016/j.cell.2011.02.013. - DOI - PubMed

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