How Do We Explore Heterogeneity in Turnover of Musculoskeletal Proteins?

Affiliations

¹ Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital-Bispebjerg and Frederiksberg, 2400 Copenhagen NV, Denmark.

Comment

Jakob Agergaard et al. Function (Oxf). 2021.

. 2021 Jun 28;2(4):zqab034.

doi: 10.1093/function/zqab034. eCollection 2021.

¹ Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital-Bispebjerg and Frederiksberg, 2400 Copenhagen NV, Denmark.

No abstract available

Comment on

A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen Proteostasis.
Abbott CB, Lawrence MM, Kobak KA, Lopes EBP, Peelor FF 3rd, Donald EJ, Van Remmen H, Griffin TM, Miller BF. Abbott CB, et al. Function (Oxf). 2021 May 10;2(4):zqab028. doi: 10.1093/function/zqab028. eCollection 2021. Function (Oxf). 2021. PMID: 34124684 Free PMC article.

1. Waterlow JC, Garlick PJ, Millward DJ. Protein Turnover in Mammalian Tissues and in the Whole Body.Amsterdam, the Netherlands: Elsevier Science Ltd; 1978.
1. Miller BF, Olesen JL, Hansen Met al. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol. 2005;567(3):1021–1033. - PMC - PubMed
1. Abbott CB, Lawrence MM, Kobak KAet al. A novel stable isotope approach demonstrates surprising degree of age-related decline in skeletal muscle collagen proteostasis. Function. 2021;2(4):1–11. - PMC - PubMed
1. Heinemeier KM, Schjerling P, Heinemeier Jet al. Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb (14)C. FASEB J. 2013;27(5):2074–2079. - PMC - PubMed
1. Heinemeier KM, Schjerling P, Heinemeier Jet al. Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage. Sci Transl Med. 2016;8(346):346ra90. - PubMed