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Review
. 2022 Apr:48:1-4.
doi: 10.1016/j.clnesp.2022.02.116. Epub 2022 Feb 24.

Severe acute respiratory syndrome and thyroid: A molecular point of view

Fatemeh Sadoughi  1 , Parisa Maleki Dana  2 , Jamal Hallajzadeh  3 , Zatollah Asemi  4 , Mohammad Ali Mansournia  5 , Bahman Yousefi  6
Affiliations
Review

Severe acute respiratory syndrome and thyroid: A molecular point of view

Fatemeh Sadoughi et al. Clin Nutr ESPEN. 2022 Apr.

Abstract

SARS-CoV-2 and some other members of Coronaviridae family have recently forced a great deal of health, social, and economic issues globally. To that end, investigations have been oriented towards finding ways for reducing the burden of COVID-19. One of the occurrences which stands in the way of making the treatment of this disease less complicated is the way coronaviruses involve a variety of cells, tissues, organs, and even systems. This action is possible as a result of viral attachment to the angiotensin-converting enzyme 2 or ACE2. Thus, any kind of cell expressing ACE2 is prone to be affected by both SARS-COV and SARS-COV-2. Endocrine system is one of these at-risk systems. In this review, we have considered the relation between coronaviruses and one of the most essential organs of endocrine system: thyroid gland. This relation can be probed from two aspects: how underlying thyroid dysfunction can increase the risk of being infected by these viruses and how these viruses can alter the function of thyroid gland.

Keywords: ACE2; COVID-19; Dysfunction; Endocrine; Metabolic disease; SARS; Thyroid.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Cellular and molecular mechanisms by which SARS-CoV-2 affects thyroid function. ACE, Angiotensin converting enzyme; TSH, Thyroid-stimulating hormone.
See this image and copyright information in PMC

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