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Editorial
. 2022 Jul;129(1):7-10.
doi: 10.1016/j.bja.2022.02.031. Epub 2022 Mar 21.

Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead

J Robert Sneyd  1
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Free article
Editorial

Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead

J Robert Sneyd. Br J Anaesth. 2022 Jul.
Free article

Abstract

Intensive care unit (ICU) sedation with sevoflurane is associated with nephrogenic diabetes insipidus. Given that isoflurane is now licenced (in Europe) for ICU sedation and has Investigational New Drug status in the USA, evidence indicates that clinicians should stop using sevoflurane in this indication except in the context of clinical trials.

Keywords: acute kidney injury; diabetes insipidus; isoflurane; nephrotoxicity; sedation; sevoflurane.

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Conflict of interest statement

Declarations of interest The author is a consultant to Paion (Aachen, Germany) and Medtronic (Watford, UK).

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