Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Mar 24;15(3):e247576.
doi: 10.1136/bcr-2021-247576.

Thrombotic thrombocytopenic purpura following administration of the Moderna booster vaccine

Emma Herrman  1 , Bipin Ghimire  2 , Mohammad Muhsin Chisti  3
Affiliations
Case Reports

Thrombotic thrombocytopenic purpura following administration of the Moderna booster vaccine

Emma Herrman et al. BMJ Case Rep. .

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a type of thrombotic microangiopathy that is characterized by microangiopathic haemolytic anaemia, consumption thrombocytopenia and organ injury. It is caused by a severe deficiency of ADAMTS13, which can be either congenital or acquired. There is a plethora of things that can cause the acquired form, including medications and infections. Vaccines have also been shown to cause TTP. In the midst of the COVID-19 pandemic, with multiple new vaccines being developed and distributed to the masses, the medical community needs to be aware of adverse events associated with these new vaccines. We present a case of TTP following administration of the Moderna booster vaccine.

Keywords: COVID-19; haematology (incl blood transfusion); immunological products and vaccines; malignant and benign haematology.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Similar articles

See all similar articles

References

    1. CDC . Different COVID-19 vaccines, 2021. Available: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines.html
    1. Lee E, Cines DB, Gernsheimer T. Thrombocytopenia following Pfizer and Moderna SARS‐CoV‐2 vaccination. Am J Hematol 2021. - PMC - PubMed
    1. Greinacher A, Thiele T, Warkentin TE, et al. . Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med 2021;384:2092–101. 10.1056/NEJMoa2104840 - DOI - PMC - PubMed
    1. Cines DB, Bussel JB. SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia. N Engl J Med 2021;384:2254–6. 10.1056/NEJMe2106315 - DOI - PMC - PubMed
    1. Schultz NH, Sørvoll IH, Michelsen AE, et al. . Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination. N Engl J Med 2021;384:2124–30. 10.1056/NEJMoa2104882 - DOI - PMC - PubMed

Publication types

MeSH terms