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Review
. 2022 Jun;477(6):1817-1828.
doi: 10.1007/s11010-022-04412-5. Epub 2022 Mar 24.

Non-coding RNAs as emerging regulators and biomarkers in colorectal cancer

Chandra Kishore  1 , Devarajan Karunagaran  2
Affiliations
Review

Non-coding RNAs as emerging regulators and biomarkers in colorectal cancer

Chandra Kishore et al. Mol Cell Biochem. 2022 Jun.

Abstract

CRC is the third most common cancer occurring worldwide and the second leading cause of cancer deaths. In the year 2020, 1,931,590 new cases of CRC and 935,173 deaths were reported. The last two decades have witnessed an intensive study of noncoding RNAs and their implications in various pathological conditions including cancer. Noncoding RNAs such as miRNAs, tsRNAs, piRNAs, lncRNAs, pseudogenes, and circRNAs have emerged as promising prognostic and diagnostic biomarkers in preclinical studies of cancer. Some of these noncoding RNAs have also been shown as promising therapeutic targets for cancer treatment. In this review, we have discussed the emerging roles of various types of noncoding RNAs in CRC and their future implications in colorectal cancer management and research.

Keywords: Biomarker; Colorectal cancer; Non-coding RNAs; Pseudogenes; circRNAs; lncRNAs; miRNAs; piRNAs; tsRNAs.

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References

    1. Arnold M, Sierra MS, Laversanne M et al (2017) Global patterns and trends in colorectal cancer incidence and mortality. Gut 66:683–691. https://doi.org/10.1136/gutjnl-2015-310912 - DOI - PubMed
    1. Dozois EJ, Boardman LA, Suwanthanma W et al (2008) Young-onset colorectal cancer in patients with no known genetic predisposition: can we increase early recognition and improve outcome? Medicine (Baltimore) 87:259–263. https://doi.org/10.1097/MD.0b013e3181881354 - DOI
    1. Arnold M, Soerjomataram I, Ferlay J, Forman D (2015) Global incidence of oesophageal cancer by histological subtype in 2012. Gut 64:381–387. https://doi.org/10.1136/gutjnl-2014-308124 - DOI - PubMed
    1. Schatoff EM, Leach BI, Dow LE (2017) Wnt signaling and colorectal cancer. Curr Colorectal Cancer Rep 13:101–110. https://doi.org/10.1007/s11888-017-0354-9 - DOI - PubMed - PMC
    1. Loboda A, Nebozhyn MV, Watters JW et al (2011) EMT is the dominant program in human colon cancer. BMC Med Genomics 4:9. https://doi.org/10.1186/1755-8794-4-9 - DOI - PubMed - PMC

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