Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2022 Apr;16(4):317-328.
doi: 10.1111/crj.13486. Epub 2022 Mar 24.

Effectiveness of 12-week inspiratory muscle training with manual therapy in patients with COPD: A randomized controlled study

Yasemin Buran Cirak  1 , Gul Deniz Yilmaz Yelvar  1 , Nurgül Durustkan Elbasi  1
Affiliations
Randomized Controlled Trial

Effectiveness of 12-week inspiratory muscle training with manual therapy in patients with COPD: A randomized controlled study

Yasemin Buran Cirak et al. Clin Respir J. 2022 Apr.

Abstract

The benefits of inspiratory muscle training (IMT) in patients with COPD were reported. However, its effects are limited in severe COPD patients. Further researches are required in new and complementary modalities demonstrating IMT efficacy in severe COPD patients. This study aims to investigate effects of manual therapy (MT) additional over IMT on functional capacity, respiratory muscle strength, pulmonary function, dyspnea, fatigue, and quality of life in severe COPD patients. Sixty patients with COPD in GOLD stage III-IV were included in this prospective single-blind randomized trial. Patients were randomly assigned to receive either MT additional over IMT at 40% of maximal inspiratory pressure (MIP) (n = 30) or only IMT (n = 30) for 12 weeks. MT group received MT during 12 weeks for 30 min additional to IMT. Pulmonary function, respiratory muscle strength, functional capacity, dyspnea, fatigue, and quality of life were evaluated by spirometry, mouth pressure device, six-minute walk test, Modified Medical Research Council (mMRC) dyspnea scale, fatigue severity scale, and St. George's Respiratory Questionnaire (SGRQ), respectively. MT group had significantly greater improvement in FEV1%, FVC%, PEF%, respiratory muscle strength, function, dyspnea, fatigue, and quality of life compared with IMT group (p < 0.05). 6MWT (p < 0.001, effect size Cohen's d: 0.915), MIP (p < 0.001, effect size Cohen's d: 1.235), and mMRC score (p < 0.001, effect size Cohen's d: 0.982) were significantly improved in IMT with MT group. This study demonstrated that subjects in IMT with MT group had improved outcomes in functional capacity, respiratory muscle strength, pulmonary function, dyspnea, fatigue perception, and quality of life compared with alone IMT group.

Keywords: COPD; functional capacity; inspiratory muscle training; manual therapy.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
Flowchart of the study
FIGURE 2
FIGURE 2
Comparison of treatment effect on pulmonary function and respiratory muscle strength between the groups
FIGURE 3
FIGURE 3
Comparison of treatment effect on functional capacity, dyspnea, fatigue and quality of life between the groups
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. (2021). Retrieved September 19, 2018. https://goldcopd.org/wp-content/uploads/2020/11/GOLD-REPORT-2021-v1.1-25...
    1. Patel ARC, Hurst JC. Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art. Expert Rev Respir Med. 2011;5(5):647‐661. doi:10.1586/ers.11.62 - DOI - PubMed
    1. Morais N, Cruz J, Marques A. Posture and mobility of the upper body quadrant and pulmonary function in COPD: an exploratory study. Braz J Phys Ther. 2016;20(4):345‐354. doi:10.1590/bjpt-rbf.2014.0162 - DOI - PMC - PubMed
    1. Couillard A, Prefaut C. From muscle disuse to myopathy in COPD: potential contribution of oxidative stress. Eur Respir J. 2005;26(4):703‐719. doi:10.1183/09031936.05.00139904 - DOI - PubMed
    1. Gosselink R. Breathing techniques in patients with chronic obstructive pulmonary disease (COPD). Chron Resp Dis. 2004;1(3):163‐172. doi:10.1191/1479972304cd020rs - DOI - PubMed

Publication types