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Review
. 2022 May;29(3):221-230.
doi: 10.1007/s40292-022-00507-8. Epub 2022 Mar 25.

Hypertension and Dyslipidemia Combined Therapeutic Approaches

Affiliations
Review

Hypertension and Dyslipidemia Combined Therapeutic Approaches

Claudio Borghi et al. High Blood Press Cardiovasc Prev. 2022 May.

Abstract

Treating blood pressure (BP) alone may provide only limited benefits while it is recommendable to manage the total cardiovascular risk. To date, several studies have shown that concomitant treatment of hypertension and dyslipidemia with non-pharmacological approaches and/or metabolically neutral antihypertensive drugs and statins produce a significantly greater reduction of the risk of developing cardiovascular disease. Thus, in this review article, we summarize the available evidence regarding non-pharmacological and pharmacological approaches with a favourable effect on both BP and lipids.

Keywords: Blood pressure; DASH; Dyslipidemia; Hypertension; PUFA; Statins.

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Conflict of interest statement

Claudio Borghi has served as a consultant for Servier, Menarini Corporate, Novartis Pharma, Novo Nordisk, Astra Zeneca, Alfasigma. Federica Fogacci, Arrigo F.G.Cicero and Davide Agnoletti have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Mechanisms involved in the interaction between hypercholesterolemia and Renin-Angiotensin system and hypertension. (from Ref. [70], mod)

References

    1. World Health Organization. Hypertension fact sheet. 2019 [cited 2021 10 October]. https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed 3 Jan 2022.
    1. Williams B, Masi S, Wolf J, Schmieder RE. Facing the challenge of lowering blood pressure and cholesterol in the same patient: report of a Symposium at the European Society of Hypertension. Cardiol Ther. 2020;9(1):19–34. doi: 10.1007/s40119-019-00159-1. - DOI - PMC - PubMed
    1. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L, INTERHEART Study Investigators Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–52. doi: 10.1016/S0140-6736(04)17018-9. - DOI - PubMed
    1. Multiple Risk Factor Intervention Trial Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA. 1982;248(12):1465–77. doi: 10.1001/jama.1982.03330120023025. - DOI - PubMed
    1. Schwalm JD, McKee M, Huffman MD, Yusuf S. Resource effective strategies to prevent and treat cardiovascular disease. Circulation. 2016;133(8):742–55. doi: 10.1161/CIRCULATIONAHA.115.008721. - DOI - PMC - PubMed

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