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. 2023 Mar;340(2):105-115.
doi: 10.1002/jez.b.23131. Epub 2022 Mar 25.

Evolution of modular and pleiotropic enhancers

Suriya N Murugesan  1 , Antónia Monteiro  1   2
Affiliations

Evolution of modular and pleiotropic enhancers

Suriya N Murugesan et al. J Exp Zool B Mol Dev Evol. 2023 Mar.

Abstract

Cis-regulatory elements (CREs), or enhancers, are segments of noncoding DNA that regulate the spatial and temporal expression of nearby genes. Sometimes, genes are expressed in more than one tissue, and this can be driven by two main types of CREs: tissue-specific "modular" CREs, where different CREs drive expression of the gene in the different tissues, or by "pleiotropic" CREs, where the same CRE drives expression in the different tissues. In this perspective, we will discuss some of the ways (i) modular and pleiotropic CREs might originate; (ii) propose that modular CREs might derive from pleiotropic CREs via a process of duplication, degeneration, and complementation (the CRE-DDC model); and (iii) propose that hotspot loci of evolution are associated with the origin of modular CREs belonging to any gene in a regulatory network.

Keywords: CREs; enhancers; evo-devo; evolution; modularity; pleiotropy.

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References

REFERENCES

    1. Arnoult, L., Su, K. Y., Manoel, D., Minervino, C., Magriña, J., Gompel, N., & Prud'homme, B. (2013). Emergence and diversification of fly pigmentation through evolution of a gene regulatory module. Science, 339(6126), 1423-1426. https://doi.org/10.1126/science.1233749
    1. Barrio, R., De Celis, J. F., bolshakov, S., & Kafatos, F. C. (1999). Identification of regulatory regions driving the expression of the Drosophila spalt complex at different developmental stages. Developmental Biology, 215(1), 33-47. https://doi.org/10.1006/dbio.1999.9434
    1. Bomblies, K., Dagenais, N., & Weigel, D. (1999). Redundant enhancers mediate transcriptional repression of AGAMOUS by APETALA2. Developmental Biology, 216(1), 260-264. https://doi.org/10.1006/dbio.1999.9504
    1. Bourque, G., Burns, K. H., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., Imbeault, M., Izsvák, Z., Levin, H. L., Macfarlan, T. S., Mager, D. L., & Feschotte, C. (2018). Ten things you should know about transposable elements. Genome Biology, 19(1), 1-12. https://doi.org/10.1186/s13059-018-1577-z
    1. Chan, Y., Melissa, F., Marks, E., Jones, F. C., Villarreal, G., Shapiro, M. D., Brady, S. D., Southwick, A. M., Absher, D. M., Grimwood, J., Schmutz, J., Myers, R. M., Petrov, D., Jónsson, B., Schluter, D., Bell, M. A., & Kingsley, D. M. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitxl enhancer. Science, 327(5963), 302-305. https://doi.org/10.1126/science.1182213

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